35776-96-6Relevant academic research and scientific papers
Triplet energy distribution in photoinitiators containing two dissociable groups
Shah, Bipin K.,Neckers, Douglas C.
, p. 6117 - 6123 (2007/10/03)
Suitable probe molecules containing the benzophenone chromophore and one dissociable bond [perester 1 or C-X (4, 5)] or two such bonds (2, 3) have been synthesized and studied to examine intramolecular triplet energy dispersion. Triplet energies and phosphorescence quantum yields as well as quantum efficiencies of bond scissions have been studied, and the flow of triplet energy in such molecules is discussed. Upon irradiation at 350 nm in either benzene or methanol, the target peresters undergo dissociation of both cleavable groups, producing a pair of radicals. The presence of a benzylic chloride function has little influence on the efficiency of perester dissociation. However, the presence of a benzylic bromide function was found to decrease the quantum yield of decomposition of the perester function of 3. This can be explained by taking into account the effect of the heavy atom and the rate of cage geminate radical pair recombination. The nature of the heavy atom perturbation, however, was found to be different in 5 as compared with 3.
Use of src SH2 specific compounds to treat a bone resorption disease
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, (2008/06/13)
Invented is a method of treating a bone resorption disease in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human src SH2 domain with a binding affinity greater than fifty-fold higher than the binding affinity with which the compound binds to a human lck SH2 domain and a human fyn SH2 domain, and, binds to a human hcp SH2 domain, a human Grb2 SH2 domain, a human SH-PTP2 SH2 domain and a human p85 SH2 domain with a binding affinity which is greater than fifty-fold lower than the binding affinity with which the compound binds to such src SH2 domain.
Regioselective Functionalization of Nonactivated CH-Bonds,3.-Synthesis and Properties of Photoreactive, Amphiphilic Benzophenone Compounds
Gogoll, Adolf,Schaefer, Hans J.
, p. 589 - 596 (2007/10/02)
Three differently substituted benzophenone-4-carboxylic acids 1e, 1g, 1h and myristic acid (2a), representing anionic, single-chain amphiphiles, and esters of 1e and 2a with quaternized β-amino alcohols as examples of single-chain (1l, 2e) and double-chai
Effect of Chain Length on Mesomorphism of Steroid Esters of 4-(4-Alkylphenyl-X)benzoic Acids with X = CO, O, S, and CH2
Koden, Mitsuhiro,Yagyu, Tadao,Takenaka, Shunsuke,Kusabayashi, Shigekazu
, p. 4730 - 4737 (2007/10/02)
To examine the effect of bent shapes on mesomorphic properties a homologous series of steroid esters have been prepared: H(CH2)n-4-C6H4-X-4-C6H4COOR, X = CO, O, S, CH2, R = cholesteryl, β-sitosteryl, cholestanyl, stigmasteryl, ergosteryl; n = 0-15.The chain elongation results in an increase in not only the molecular length but also the breadth due to the angular linkage, X.The steroid portions are of primary importance for the mesomorphic properties of the present series, and the thermal stability of the mesophases is strongly dependent on the mesogenic power of the aryl portions, where the effective order is CO > O > S > CH2.The transition enthalpies and entropies for the smectic A-cholesteric and cholesteric-isotropic (Ch-I) transitions are almost independent of the chain length of the alkyl group, indicating that a long alkyl chain has no role from a thermodynamical piont of view.Within the mesophases, the aryl and steroid cores are assumed to be piled up, interacting with each other, and the alkyl groups are apart from each other to avoid short-range interaction.
