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2-amino-5-butyl-6-phenylpyrimidin-4(1H)-one is a chemical compound with the molecular formula C15H18N2O. It is a derivative of pyrimidin-4(1H)-one, featuring an amino group at the 2-position, a butyl chain at the 5-position, and a phenyl group at the 6-position. 2-amino-5-butyl-6-phenylpyrimidin-4(1H)-one is known for its potential applications in medicinal chemistry, particularly as a building block for the synthesis of various biologically active molecules. Its structure allows for the exploration of different pharmacological properties, making it a valuable compound in the development of new drugs and therapeutic agents.

7377-47-1

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7377-47-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7377-47-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,7 and 7 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7377-47:
(6*7)+(5*3)+(4*7)+(3*7)+(2*4)+(1*7)=121
121 % 10 = 1
So 7377-47-1 is a valid CAS Registry Number.

7377-47-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-5-butyl-6-phenyl-1H-pyrimidin-4-one

1.2 Other means of identification

Product number -
Other names 2-amino-5-butyl-6-phenyl-3H-pyrimidin-4-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:7377-47-1 SDS

7377-47-1Relevant academic research and scientific papers

Development of Scalable Synthesis of 5-Butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (WQE-134), a Dual Inhibitor of Nitric Oxide and Prostaglandin E2Production

Baszczyňski, Ond?ej,Dosoudil, Pavel,Havránek, Miroslav,Janeba, Zlatko,Kaiser, Martin Maxmilian,Kolman, Viktor,Kotek, Vladislav

, p. 1718 - 1724 (2020/10/26)

We report a scalable efficient synthesis of 5-butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (WQE-134), a dual inhibitor of nitric oxide and prostaglandin E2 production with potent anti-inflammatory properties. The original five-step synthesis (40% overall yield) was based on two Suzuki-Miyaura reactions and required chromatographic purification of both the intermediate and final products. The novel synthetic pathway is based on cyclization of 2-butyl-1-(4-methoxyphenyl)-3-phenylpropane-1,3-dione with guanidinium methanesulfonate using Eaton's reagent (P2O5/MsOH) at 50 °C. The two-step synthesis (34% overall yield) can be performed on a multigram to kilogram scale, and purification of the final product consists of simple extraction (dichloromethane) and crystallization (ethyl acetate and methanol).

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