7377-98-2Relevant articles and documents
Catalytic Sc(OTf)3 mediated direct asymmetric aldol reaction of (?)-menthyl isothiocyanatoacetate with aldehydes by using (?)-menthol as chiral auxiliary
Bhangare, Dattatraya N.,Shinde, Rohit G.,Pawar, Pushpalata D.,Nikalje, Milind D.,Lokhande, Mahendra N.
supporting information, p. 1878 - 1882 (2021/05/27)
This method involves the direct asymmetric aldol reaction of (?)-menthyl isothiocyanatoacetate 5 with a variety of substituted aromatic aldehydes, which offers a convenient method for the synthesis of intermediate containing biologically relevant α-amino
Synthesis, characterization and physicochemical properties of new chiral quinuclidinol quaternary ammonium salts
Li, Ruoheng,Li, Zicheng,Song, Hang,Wang, Zhixia,Xu, Qiwei,Yao, Shun
, (2020/03/10)
A new series of chiral quaternary ammonium salts (QASs) were successfully synthesized and characterized by FT-IR, NMR and MS. The thermal stability and melting point (mp) of the chiral QASs were measured. Moreover, basic physicochemical properties of the
Preparation method of Gboxin
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Paragraph 0022; 0031-0033; 0043-0045; 0054-0056, (2020/08/27)
The invention relates to a preparation method of Gboxin. The method comprises the following steps: reacting o-phenylenediamine with n-propanal; preparing 2-ethyl-1H-benzimidazole, carrying out N-alkylation reaction on 2-ethyl-1H-benzimidazole and chloroacetic acid-L-menthyl ester to generate 2-(2-ethyl-1H-benzimidazole) L-menthyl acetate, carrying out methylation by using iodomethane to generate abenzimidazolium salt, and finally, exchanging iodine ions into chloride ions by using chlorine ion exchange resin to obtain the final product Gboxin. The method has the advantages of short process route, mild conditions, simple operation and low equipment requirements, and the obtained product has the advantages of high purity and high yield, and is suitable for industrial production.