130156-93-3Relevant academic research and scientific papers
Facile synthesis of a chiral auxiliary bearing the isocyanide group
Ilankumaran, Palanichamy,Kisanga, Philip,Verkade, John G.
, p. 561 - 562 (2001)
A previous study synthesized a chiral auxiliary bearing the isocyanide functionality in six steps and with an oxazoline functionality. This paper discusses the synthesis of a chiral isocyanide possessing the easily cleaved menthoxy group. The synthesis pr
Catalytic Sc(OTf)3 mediated direct asymmetric aldol reaction of (?)-menthyl isothiocyanatoacetate with aldehydes by using (?)-menthol as chiral auxiliary
Bhangare, Dattatraya N.,Shinde, Rohit G.,Pawar, Pushpalata D.,Nikalje, Milind D.,Lokhande, Mahendra N.
supporting information, p. 1878 - 1882 (2021/05/27)
This method involves the direct asymmetric aldol reaction of (?)-menthyl isothiocyanatoacetate 5 with a variety of substituted aromatic aldehydes, which offers a convenient method for the synthesis of intermediate containing biologically relevant α-amino
An efficient synthesis of phosphoramidates from halides in aqueous ethanol
Dangroo,Dar,Shankar,Khuroo,Sangwan
, p. 2717 - 2722 (2016/06/09)
An environment friendly and efficient synthesis of primary phosphoramidates has been developed from benzyl/allyl/alkyl/propargyl halides in aqueous ethanol as a green reaction medium via in-situ formation of azide. The method is simple, metal free and high yielding at room temperature with wide substrate scope and functional group compatibility. The optimized protocol can be used for synthesis of phosphoramidate intermediates used as prodrug moieties to improve therapeutic potential of the parent drug.
