73773-15-6

Basic information

• Product Name: (S)-p-tolyl(p-(trifluoromethyl)phenyl)methanol
• Synonyms: (S)-p-tolyl(p-(trifluoromethyl)phenyl)methanol
• CAS NO: 73773-15-6
• Molecular Weight: 266.263
• Mol File: 73773-15-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-p-tolyl(p-(trifluoromethyl)phenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-p-tolyl(p-(trifluoromethyl)phenyl)methanol(73773-15-6)
• EPA Substance Registry System: (S)-p-tolyl(p-(trifluoromethyl)phenyl)methanol(73773-15-6)

Safety Data

• Hazardous Substances Data: 73773-15-6(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 5084-80-0 tri(4-tolyl)boroxine 
• 104-87-0 4-methyl-benzaldehyde 
• 128796-45-2 2,4,6-tris-(4-trifluoromethylphenyl)boroxine 
• 34328-30-8 4-trifluoromethyl-4′-methylbenzophenone 

Relevant articles and documents

Enantioselective Diarylcarbene Insertion into Si-H Bonds Induced by Electronic Properties of the Carbenes

Catalytic enantioselection usually depends on differences in steric interactions between prochiral substrates and a chiral catalyst. We have discovered a carbene Si-H insertion in which the enantioselectivity depends primarily on the electronic characteristics of the carbene substrate, and the log(er) values are linearly related to Hammett parameters. A new class of chiral tetraphosphate dirhodium catalysts was developed; it shows excellent activity and enantioselectivity for the insertion of diarylcarbenes into the Si-H bond of silanes. Computational and mechanistic studies show how the electronic differences between the two aryls of the carbene lead to differences in energies of the diastereomeric transition states. This study provides a new strategy for asymmetric catalysis exploiting the electronic properties of the substrates.

Practical implications of boron-to-zinc transmetalation for the catalytic asymmetric arylation of aldehydes

(Chemical Equation Presented) Faster than believed: Transmetalation from aryl boronic acids and triaryl boroxines to diethylzinc takes place within minutes following a two-step, low-energy pathway (see picture), according to density functional calculations and reaction microcalorimetry measurements. The experimental conditions for a practical, atom-economical, and highly enantioselective catalytic arylation of a variety of aldehydes have been developed from these data.