73792-22-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-amino-3-fluorophenyl)ethan-1-one is used as a starting material for the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of derivatives with potential therapeutic applications.
Used in Chemical Synthesis:
1-(4-amino-3-fluorophenyl)ethan-1-one serves as a key intermediate in the preparation of complex organic molecules, particularly in the synthesis of 2-Amino-5-[(cyclopentylamino)acetyl]-3-fluoro-benzonitrile. 1-(4-amino-3-fluorophenyl)ethan-1-one is an example of how 1-(4-amino-3-fluorophenyl)ethan-1-one can be utilized to produce molecules with specific properties and potential applications in various fields.

InChI:InChI=1/C8H8FNO/c1-5(11)6-2-3-8(10)7(9)4-6/h2-4H,10H2,1H3

Upstream product

• 369-33-5 3',4'-difluoroacetophenone 
• 111-34-2 -butyl vinyl ether 
• 29632-74-4 2-fluro-4-iodoaniline 
• 97760-95-7 4-acetylamino-3-fluoro-benzaldehyde 
• 93129-68-1 4-acetylamino-3-fluoro-benzonitrile 
• 97760-94-6 N-(2-fluoro-4-iodo-phenyl)-acetamide 
• 348-54-9 2-Fluoroaniline 
• 85117-88-0 4'-acetylamino-3'-fluoro-acetophenone 

Downstream Products

• 811799-85-6 1-(4-acetyl-2-fluorophenyl)-3-amino-2-pyrrolidinone 
• 54240-29-8 1-(4-Amino-3-bromo-5-fluoro-phenyl)-2-(2-benzo[1,3]dioxol-5-yl-1-methyl-ethylamino)-ethanone 
• 54238-93-6 1-(4-Amino-3-chloro-5-fluoro-phenyl)-2-(2-benzo[1,3]dioxol-5-yl-1-methyl-ethylamino)-ethanone 
• 56340-31-9 4'-amino-3'-cyano-2-cyclopentylamino-5'-fluoroacetophenone 
• 56340-10-4 1-(4-Amino-3-bromo-5-fluoro-phenyl)-2-cycloheptylamino-ethanone 
• 56340-27-3 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone 
• 56340-25-1 4'-amino-3'-cyano-5'-fluoro-2-isopropylaminoacetophenone 
• 56340-23-9 4'-amino-3'-cyano-2-cyclopropylamino-5'-fluoroacetophenone 
• 56340-33-1 4'-amino-3'-cyano-5'-fluoro-2-tert-pentylaminoacetophenone 
• 685496-26-8 1-(4-Amino-3-chloro-5-fluoro-phenyl)-2-isopropylamino-ethanone 
• 83979-26-4 4-amino-3-cyano-5-fluoro-phenacyl bromide 
• 56340-12-6 4'-amino-2-cyclopropylamino-3'-fluoro-5'-iodo-acetophenone 
• 754919-70-5 1-(4-Amino-3-chloro-5-fluoro-phenyl)-2-cyclopropylamino-ethanone 
• 56340-29-5 4'-amino-2-tert-butylamino-3'-cyano-5'-fluoroacetophenone 

Relevant academic research and scientific papers

Silver-catalyzed intermolecular amination of fluoroarenes

A novel highly selective Ag-catalyzed intermolecular amination of fluoroarenes has been developed. This transformation starts from readily available 4-carbonyl fluorobenzene and NaN3 or other nitrogen-source, via amination followed by C-F bond cleavage, thus affording the desired 4-carbonyl arylamine products under mild conditions. The reaction is accelerated using a small amount of water. This pathway is distinct from a previously reported radical amination reaction.

Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same

This present invention relates to compounds of formula (I), in which R3 represents C2-C5 alkenyl or C2-C5 alkynyl and the other variables are as defined in the claims, isomers thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonists; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating pain, inflammatory disease of the joints, urinary bladder hypersensitivity including urinary incontinence, stomach duodenal ulcer, irritable bowel syndrome, inflammatory bowel disease, neurotic/allergic/inflammatory skin disease, psoriasis, asthma, chronic obstructive pulmonary disease, pruritus or prurigo.

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receotor 1; VR1; TRPV1 )antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.