73792-22-0

Basic information

• Product Name: 1-(4-amino-3-fluorophenyl)ethan-1-one
• Synonyms: 1-(4-amino-3-fluorophenyl)ethan-1-one;Ethanone, 1-(4-amino-3-fluorophenyl)- (9CI);1-(4-Amino-3-fluorophenyl)ethanone;4'-Amino-3'-fluoroacetophenone;3-Fluoro-4-aminoacetophenone;4-Acetyl-2-fluoroaniline
• CAS NO: 73792-22-0
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.1536232
• EINECS: 277-610-0
• Product Categories: ACETYLGROUP;Fluorine series
• Mol File: 73792-22-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 86-88℃
• Boiling Point: 286℃
• Flash Point: 127℃
• Appearance: /
• Density: 1.201
• Vapor Pressure: 0.00265mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: 2-8°C(protect from light)
• PKA: 0.77±0.10(Predicted)
• CAS DataBase Reference: 1-(4-amino-3-fluorophenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-amino-3-fluorophenyl)ethan-1-one(73792-22-0)
• EPA Substance Registry System: 1-(4-amino-3-fluorophenyl)ethan-1-one(73792-22-0)

Safety Data

• Hazardous Substances Data: 73792-22-0(Hazardous Substances Data)

Usage

Uses

1-(4-Amino-3-fluorophenyl)ethanone can be used as a starting material in the preparation of 2-Amino-5-[(cyclopentylamino)acetyl]-3-fluoro-benzonitrile.

InChI:InChI=1/C8H8FNO/c1-5(11)6-2-3-8(10)7(9)4-6/h2-4H,10H2,1H3

Upstream product

• 348-54-9 2-Fluoroaniline 
• 29632-74-4 2-fluro-4-iodoaniline 
• 111-34-2 -butyl vinyl ether 
• 369-33-5 3',4'-difluoroacetophenone 
• 97760-95-7 4-acetylamino-3-fluoro-benzaldehyde 
• 93129-68-1 4-acetylamino-3-fluoro-benzonitrile 
• 97760-94-6 N-(2-fluoro-4-iodo-phenyl)-acetamide 
• 85117-88-0 4'-acetylamino-3'-fluoro-acetophenone 

Downstream Products

• 95656-56-7 1-(4'-Amino-3'-fluoro-5'-iodo-phenyl)-2-tert-butylamino-ethanol 
• 97776-50-6 1-(4'-Amino-3'-bromo-5'-fluoro-phenyl)-2-tert-pentylamino-ethanol 
• 54240-25-4 4'-amino-3'-bromo-2-cyclopropylamino-5'-fluoro-acetophenone 
• 745725-51-3 1-(4-Amino-3-bromo-5-fluoro-phenyl)-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone 
• 56340-21-7 2-Amino-5-(2-ethylamino-acetyl)-3-fluoro-benzonitrile 
• 752925-84-1 1-(4-Amino-3-bromo-5-fluoro-phenyl)-2-isopropylamino-ethanone 
• 97776-46-0 1-(4'-Amino-3'-bromo-5'-fluoro-phenyl)-2-cyclopropylamino-ethanol 
• 56340-15-9 4'-amino-2-cyclobutylamino-3'-fluoro-5'-iodo-acetophenone 
• 54240-26-5 2-[2-(4-Amino-3-bromo-5-fluoro-phenyl)-2-hydroxy-ethylamino]-2-methyl-propan-1-ol 
• 97760-50-4 2-[2-(4-Amino-3-fluoro-5-iodo-phenyl)-2-hydroxy-ethylamino]-2-methyl-propan-1-ol 
• 97760-51-5 2-Amino-5-(2-ethylamino-1-hydroxy-ethyl)-3-fluoro-benzonitrile 
• 56340-07-9 4'-amino-3'-bromo-2-cyclopentylamino-5'-fluoroacetophenone 
• 97760-49-1 1-(4'-Amino-3'-fluoro-5'-iodo-phenyl)-2-cyclobutylamino-ethanol 
• 97776-49-3 1-(4'-Amino-3'-bromo-5'-fluoro-phenyl)-2-cyclopentylamino-ethanol 

Relevant articles and documents

Silver-catalyzed intermolecular amination of fluoroarenes

A novel highly selective Ag-catalyzed intermolecular amination of fluoroarenes has been developed. This transformation starts from readily available 4-carbonyl fluorobenzene and NaN3 or other nitrogen-source, via amination followed by C-F bond cleavage, thus affording the desired 4-carbonyl arylamine products under mild conditions. The reaction is accelerated using a small amount of water. This pathway is distinct from a previously reported radical amination reaction.

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receotor 1; VR1; TRPV1 )antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.