84731-71-5

Usage

Structure

Contains a phenyl ring with a fluorine atom at the 3rd position, an iodine atom at the 5th position, and an amino group at the 4th position.

Functional groups

Amino (-NH2), carbonyl (C=O), and halogen (fluorine and iodine) groups.

Type of compound

Synthetic organic molecule

Applications

Used in medicinal and pharmaceutical research for its potential pharmacological properties.

Importance

Valuable tool for studying interactions between organic molecules and biological systems.

Potential uses

May have applications in the development of new drugs and therapeutic agents.

Further research

Necessary to fully understand its biological activity and potential uses.

InChI:InChI=1/C8H7FINO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3

Upstream product

• 73792-22-0 1-(4-amino-3-fluorophenyl)ethanone 
• 348-54-9 2-Fluoroaniline 
• 97760-94-6 N-(2-fluoro-4-iodo-phenyl)-acetamide 
• 85117-88-0 4'-acetylamino-3'-fluoro-acetophenone 
• 97760-95-7 4-acetylamino-3-fluoro-benzaldehyde 
• 93129-68-1 4-acetylamino-3-fluoro-benzonitrile 
• 29632-74-4 2-fluro-4-iodoaniline 

Downstream Products

• 911124-25-9 (R)-2-methylpropane-2-sulfinic acid (R)-[1-(4-amino-3-fluoro-5-iodophenyl)ethyl]amide 
• 56340-31-9 4'-amino-3'-cyano-2-cyclopentylamino-5'-fluoroacetophenone 
• 56340-27-3 4'-amino-3'-cyano-2-cyclobutylamino-5'-fluoroacetophenone 
• 56340-25-1 4'-amino-3'-cyano-5'-fluoro-2-isopropylaminoacetophenone 
• 56340-23-9 4'-amino-3'-cyano-2-cyclopropylamino-5'-fluoroacetophenone 
• 56340-33-1 4'-amino-3'-cyano-5'-fluoro-2-tert-pentylaminoacetophenone 
• 83979-26-4 4-amino-3-cyano-5-fluoro-phenacyl bromide 
• 56340-12-6 4'-amino-2-cyclopropylamino-3'-fluoro-5'-iodo-acetophenone 
• 56340-29-5 4'-amino-2-tert-butylamino-3'-cyano-5'-fluoroacetophenone 
• 95656-62-5 1-(4'-Amino-3'-cyano-5'-fluoro-phenyl)-2-isopropylamino-ethanol 
• 97760-47-9 1-(4'-Amino-3'-fluoro-5'-iodo-phenyl)-2-cyclopropylamino-ethanol 
• 94850-93-8 1-(4'-Amino-3'-cyano-5'-fluoro-phenyl)-2-tert-butylamino-ethanol 
• 97760-49-1 1-(4'-Amino-3'-fluoro-5'-iodo-phenyl)-2-cyclobutylamino-ethanol 
• 97760-51-5 2-Amino-5-(2-ethylamino-1-hydroxy-ethyl)-3-fluoro-benzonitrile 

Relevant academic research and scientific papers

Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same

This present invention relates to compounds of formula (I), in which R3 represents C2-C5 alkenyl or C2-C5 alkynyl and the other variables are as defined in the claims, isomers thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonists; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating pain, inflammatory disease of the joints, urinary bladder hypersensitivity including urinary incontinence, stomach duodenal ulcer, irritable bowel syndrome, inflammatory bowel disease, neurotic/allergic/inflammatory skin disease, psoriasis, asthma, chronic obstructive pulmonary disease, pruritus or prurigo.

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receotor 1; VR1; TRPV1 )antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.