73812-87-0Relevant academic research and scientific papers
Tapioca cellulose based copper nanoparticles for chemoselective N-alkylation
Islam, Md. Shaharul,Mandal, Bablu Hira,Biswas, Tapan Kumar,Rahman, Md. Lutfor,Rashid,Tan, Suat-Hian,Sarkar, Shaheen M.
, p. 550 - 557 (2017/01/05)
Biomaterials as a support for catalysts are of prime importance. Tapioca root which is an abundant biopolymer source was used to synthesize cellulose supported bio-heterogeneous poly(hydroxamic acid) copper nanoparticles (CuN@PHA) and was characterized by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), field emission scanning electron microscopy (FESEM), X-ray photoelectron spectroscopy (XPS), inductively coupled plasma atomic emission spectroscopy (ICP-AES), transmission electron microscopy (TEM) analyses. The tapioca cellulose supported CuN@PHA (50 mol ppm) effectively catalyzed N-alkylation reaction of aliphatic amines with α,β-unsaturated compounds to give the corresponding alkylated products. High yields up to 95% were achieved for the converted products. The reusability of the cellulose supported nanoparticles was found to be excellent with no significant reduction of its catalytic activity over several cycles. The catalyst showed high catalytic activity having turnover number (TON) 18000 and turnover frequency (TOF) 2250 h-1.
Waste corn-cob cellulose supported bio-heterogeneous copper nanoparticles for aza-Michael reactions
Sarkar, Shaheen M.,Sultana,Biswas, Tapan Kumar,Rahman, Md. Lutfor,Yusoff, Mashitah Mohd
, p. 497 - 502 (2016/01/12)
Bio-heterogeneous poly(amidoxime) copper nanoparticles were prepared on the modified surface of waste corn-cob cellulose through a graft copolymerization process. The Cu-nanoparticles (0.05 mol% to 50 mol ppm) selectively promoted the aza-Michael reaction of aliphatic amines to give the corresponding alkylated products at room temperature in methanol. The supported nanoparticles were easy to recover and reused eight times without a significant loss of their activity.
Aza-Michael reaction: Selective mono- versus bis-addition under environmentally-friendly conditions
Bosica, Giovanna,Spiteri, Jonathan,Borg, Caroline
, p. 2449 - 2454 (2014/04/03)
Aza-Michael reactions between primary amines and methyl propenoate have been investigated under environmentally-friendly solventless heterogeneous catalysis in order to obtain the mono- or the bis-adduct. The reaction conditions can be altered so as to maximise the yields of the required product with high selectivity.
Novel symmetrical trans-bis-Schiff bases of N-substituted-4- piperidones: Synthesis, characterization, and preliminary antileukemia activity mensurations
Sun, Chuan-Wen,Wang, Hai-Feng,Zhu, Jun,Yang, Ding-Rong,Xing, Jiahua,Jin, Jia
, p. 1374 - 1380 (2014/01/06)
A series of novel symmetrical trans-bis-Schiff bases (11a, 11b, 11c, 11d, 11e, 11f, 11g, 11h, 11i, 11j, 11k, 11l, 11m) were designed and prepared as novel anticancer analogues, with the trans-configuration confirmed by X-ray diffraction. Preliminary inhibitory effects of these compounds on CML K562 cell growth were investigated, and the potential analogue 11e showed an excellent anti-leukemia activity (IC50=6.35 μg/mL), which is higher than that of the clinical drug 5-fluorouracil (IC50=8.48 μg/mL). Complete assignments had been achieved for the title compounds by spectroscopic techniques, and their structure-activity relationships have been studied.
Complex containing a Lewis acid and Bronsted acid for the catalytic reactions of aza-Michael addition
Mao, Xin-Xin,Wang, Jiao,Xia, Qun-Hua,Shen, Yong-Miao
body text, p. 525 - 528 (2011/10/31)
The novel efficient complex catalyst containing a Lewis acid and a Bronsted acid have been prepared by the reaction of proline ion liquid and cuprous iodide. The catalyst was characterized by FT-IR techniques using pyridine as probe molecule. A fast, mild, and quantitative procedure for aza-Michael addition reactions between various amines and α,β- unsaturated carbonyl compounds and nitriles has been developed using the novel complex catalyst. The results showed that the novel catalyst owned high activities for the reactions with excellent yields within 1 min.
Clay catalyzed chemoselective Michael type addition of aliphatic amines to α,β-ethylenic compounds
Shaikh, Nadim S.,Deshpande, Vishnu H.,Bedekar, Ashutosh V.
, p. 9045 - 9048 (2007/10/03)
Application of acidic clays as heterogeneous catalysts for the Michael type addition reaction of aliphatic amines to α,β-ethylenic compounds is presented. Aromatic amines do not participate in this transformation.
Imine-Enamine Tautumerism - Nucleophilic Reactions of Imines
Atta-ur-Rahman,Ahmad, Viqar Uddin,Sultana, Mumtaz,Perveen, Nusrat,Sultana, Nighat
, p. 757 - 761 (2007/10/02)
A reinvestigation of the reactivity of N-isopropylidene cyclohexylamine to methyl acrylate by GC-MS analysis has shown that the major product is the β-aminoester (9) formed by the N-alkylation of cyclohexylamine which may be generated by a dimerisation-elimination sequence.A number of other products resulting from N- and C-alkylation of the ketimine have been identified. - Key words: Enamines, Ketimines, Nucleophiles, Alkylation
