73818-15-2

Basic information

• Product Name: 1-{[bis(2-hydroxyethyl)amino]methyl}-5-iodo-1H-indole-2,3-dione
• Synonyms: 1-((Bis(2-hydroxyethyl)amino)methyl)-5-iodo-1H-indole-2,3-dione; 1H-Indole-2,3-dione, 1-((bis(2-hydroxyethyl)amino)methyl)-5-iodo-
• CAS NO: 73818-15-2
• Molecular Formula: C₁₃H₁₅IN₂O₄
• Molecular Weight: 390.1737
• Mol File: 73818-15-2.mol

Chemical Properties

• Boiling Point: 566.8°C at 760 mmHg
• Flash Point: 296.6°C
• Density: 1.823g/cm³
• Vapor Pressure: 1.1E-13mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: 1-{[bis(2-hydroxyethyl)amino]methyl}-5-iodo-1H-indole-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{[bis(2-hydroxyethyl)amino]methyl}-5-iodo-1H-indole-2,3-dione(73818-15-2)
• EPA Substance Registry System: 1-{[bis(2-hydroxyethyl)amino]methyl}-5-iodo-1H-indole-2,3-dione(73818-15-2)

Safety Data

• Hazardous Substances Data: 73818-15-2(Hazardous Substances Data)

Upstream product

• 540-37-4 p-aminoiodobenzene 
• 50-00-0 formaldehyd 
• 20780-76-1 5-iodoisatin 
• 111-42-2 2,2'-iminobis[ethanol] 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 14426-21-2 diethanolamine hydrochloride 

Relevant articles and documents

Effects of isatin N-mannich bases of HeLa cells

A congeneric series of 5-haloisatins was synthesised and tested for biological activity. Mannich bases and hydrazones of 5-chloro- and 5-iodoisatin were prepared and their structures were determined spectrophotometrically. Morphological deformations and inhibition of radiolabelled precursor incorporation into DNA were studied in HeLa cell culture; antimitotic activity was examined using a phyto test with Lepidium sativum L. I50 values were determined for the most interesting compounds. The results obtained can be interpreted in terms of the group contributions to the parent molecule. Introduction of iodine into the aromatic moiety of isatin (position 5) considerably increased inhibitory potency of the parent molecule. Furthermore, N-bis-(2-chloroethyl) and N-bis-(2-hydroxyethyl) groups, respectively, as amino components of some of the N-Mannich bases, markedly enhance the biological activities studied in this work.