7382-40-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-METHYLPHENYL)-1-HYDRAZINECARBOTHIOAMIDE is used as a pharmaceutical intermediate for the development of new drugs, leveraging its unique chemical structure to contribute to the creation of innovative therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(4-METHYLPHENYL)-1-HYDRAZINECARBOTHIOAMIDE is used as a building block to construct more complex organic compounds, facilitating the synthesis of a wide range of chemical products.
Used in Agricultural Applications:
2-(4-METHYLPHENYL)-1-HYDRAZINECARBOTHIOAMIDE may be utilized in agricultural processes, potentially serving as a component in the development of agrochemicals or contributing to crop protection strategies.
Used in Industrial Processes:
2-(4-METHYLPHENYL)-1-HYDRAZINECARBOTHIOAMIDE may also find applications in various industrial processes, where its unique properties could be harnessed for specific technical or manufacturing purposes, pending further exploration and development.

InChI:InChI=1/C8H11N3S/c1-6-2-4-7(5-3-6)10-11-8(9)12/h2-5,10H,1H3,(H3,9,11,12)

Upstream product

• 637-60-5 p-tolylhydrazine hydrochloride 
• 333-20-0 potassium thioacyanate 
• 1147550-11-5 ammonium thiocyanate 
• 52384-98-2 C₈H₈NS₂^(1-)*K⁽¹⁺⁾ 
• 106-49-0 p-toluidine 
• 539-44-6 N-4-methylphenylhydrazine 

Downstream Products

• 125143-11-5 4-methyl-2-<2-(4-methylphenyl)hydrazino>thiazole 
• 125143-14-8 2-amino-4-methyl-5-(1-methyl-4-imino-2,5-cyclohexadienyl)thiazole dihydrochloride 
• 152095-11-9 2′-benzoylpyridine 4-(p-methylphenyl)-3-thiosemicarbazone 
• 918823-28-6 C₁₉H₂₄N₄O₃S₂ 
• 918822-77-2 C₁₆H₁₇N₃O₃S₂ 
• 1579938-96-7 C₁₉H₁₈ClN₃O₃S₂ 
• 918824-77-8 C₁₆H₁₅N₃O₂S₂ 
• 1579939-24-4 4-(3-(2-(1-hydroxyureido)ethylthio)-1-p-tolyl-1H-1,2,4-triazol-5-yl)benzenesulfonamide 
• 1579939-23-3 C₂₂H₂₈N₆O₄S₂ 
• 1242163-42-3 1-hydroxy-1-(2-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)ethyl)urea 
• 1242163-49-0 N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide 
• 1579938-69-4 C₂₁H₂₃N₃O₄S₂ 
• 1579939-17-5 C₂₁H₂₇N₅O₃S₂ 
• 1579938-84-3 N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide 

Relevant academic research and scientific papers

Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy

Inflammation plays a key role in cancer initiation and propagation. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), two important enzymes in inflammatory responses are up-regulated in various tumor types. Dual inhibition of COX-2 and 5-LOX constitutes a rational concept for the design of more efficacious anti-tumor agents with an improved safety profile. We have previously reported a series of diaryl-1,2,4-triazole derivatives as selective COX-2 inhibitors. Herein, we hybridized the diaryl-1,2,4-triazoles with caffeic acid (CA) which was reported to display 5-LOX inhibitory and anti-tumor activities, affording a novel class of COX-2/5-LOX dual inhibitors as anti-tumor drug candidates. Most of these compounds exhibited potent COX-2/5-LOX inhibitory and antiproliferative activities in vitro. And the most potent compound 22b could significantly inhibit tumor growth in vivo. Furthermore, mechanistic investigation showed that the representative compound 15c blocked cell cycle in G2 phase and induced apoptosis in human non-small cell lung cancer A549 cells in a dose-dependent manner. Our preliminary investigation results would provide new clues for the cancer theatment with COX-2/5-LOX dual inhibitors.

Discovery of potential anti-inflammatory drugs: Diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase

A series of hybrids from diaryl-1,2,4-triazole and hydroxamic acid or N-hydroxyurea were synthesized and evaluated as novel anti-inflammatory agents. The biological data showed that (i) all the compounds showed dual COX-2/5-LOX inhibitory activities in vitro, and 15e showed optimal inhibitory activities (COX-2: IC50 = 0.15 μM, 5-LOX: IC50 = 0.85 μM), (ii) 15e selectively inhibited COX-2 relative to COX-1 with selectivity index (SI = 0.012) comparable to celecoxib (SI = 0.015), (iii) 15e exhibited potent anti-inflammatory activity (inhibition: 54.1%) which was comparable to the reference drug celecoxib (inhibition: 46.7%) in a xylene-induced ear edema assay, and (iv) 15e displayed promising analgesic activity in acetic acid-induced writhing response and hot-plate assay. Finally, a molecular modeling study revealed the binding interactions of 15e with COX-2 and 5-LOX. Our findings suggest that 15e may be a promising anti-inflammatory agent for further evaluation.

Structure-activity studies of 4-phenyl-substituted 2′-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity

2′-Benzoylpyridine thiosemicarbazones (BpT) are effective iron chelators and display potent anti-proliferative activity against tumour cells. In order to gain greater insight into the structure-activity relationships of the BpT chelators, ten new analogue

Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal

The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilizing reducing sugars onto solid supports and methods to obtain sugars from a glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid phase Edman degradation followed by separating and characterizing the sugars.

Anthelmintic 2 arylhydrazino and 2 arylazo 2 thiazolines

Some 2 arylhydrazino and 2 arylazo 2 thiazolines were synthesized for anthelmintic testing. The most potent compound, 2 (o tolylazo) 2 thiazoline, was orally effective in sheep against a broad range of helminths.