73841-32-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-Iodopyridine-2-carboxylic acid is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals for its ability to contribute to the development of new compounds with specific therapeutic or pesticidal properties.
Used in Organic Synthesis:
3-Iodopyridine-2-carboxylic acid is used as a valuable building block in organic synthesis, enabling the preparation of heterocyclic compounds, which are important in the creation of complex organic molecules with diverse applications.
Used in Research and Development:
3-Iodopyridine-2-carboxylic acid is utilized in research and development settings to explore its potential applications and properties, furthering the understanding of its role in chemical reactions and its ability to form new compounds with unique characteristics.

InChI:InChI=1/C6H4INO2/c7-4-2-1-3-8-5(4)6(9)10/h1-3H,(H,9,10)

Upstream product

• 57841-90-4 3-iodo-N-phenyl-2-pyridinecarboxamide 
• 10354-53-7 N-phenylpicolinamide 
• 98-98-6 2-Picolinic acid 
• 1462-86-8 3-amino-pyridine-2-carboxylic acid 

Downstream Products

• 73841-41-5 3-iodo-pyridine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide

Several unnatural derivatives of narciclasine were prepared in which the C-7 carbon was replaced with nitrogen. The 7-aza derivative and its N-oxide were prepared by the coupling of iodopicolinic acid with a conduramine unit derived chemoenzymatically from bromobenzene. Intramolecular Heck reaction was used to construct the isocarbostyryl ring system. The compounds were submitted to biological screening against cancer cell lines. Full experimental and spectra data are provided for all new compounds.

Heteroaryl amide derivative and use thereof as TGR5 agonist

The invention belongs to the technical field of medicines, and in particular relates to a heteroaryl amide TGR5 agonist compound represented by formula (I) and pharmaceutically acceptable salts, esters, stereoisomers or prodrugs thereof, wherein R1, R2, R

Piperazine Heteroaryl Derivatives as Gpr38 Agonists

The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Z, X and B are as defined in the specification. The compounds are partial or full agonists at the GPR38 receptor. Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.

PIPERAZINE HETEROARYL DERIVATES AS GPR38 AGONISTS

The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, (I) wherein R1, R2, R3, R4, R5, R6, Z, X and B are as defined in the specification. The compounds are partial or full agonists at the GPR38 receptor. Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.

ADAMANTYL DERIVATES AS P2X7 RECEPTOR ANTAGONISTS

The invention provides compounds of formula (I) pharmaceutically acceptable salt or solvate thereof, in which R1, A1, m and A are as defined in the specification; a process for their preparation; pharmaceutical compositions containin

Directed lithiation of unprotected pyridinecarboxylic acids: Syntheses of halo derivatives

Deprotonation of all isomeric lithium pyridinecarboxylates and subsequent trapping with hexachloroethane or iodine afforded straightforward access to chloro- and iodopyridinecarboxylic acids, respectively. Starting from lithium 5-bromonicotinate, the introduction of an iodine atom at C4 and further halogen migration allowed the potential of this method to be extended to the synthesis of more elaborate derivatives.

Application of organolithium compounds in organic synthesis. Part 19. Synthetic strategies based on aromatic metallation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids

The synthesis of the halogenated picolin- and isonicotinalides (3) and (4) via metallation (n-BuLi) of the anilides (1) and (2) and then the reaction of the generated bis-lithiated anilides with halogenating agents (CCl3-CCl3, CH2Br-CH2Br, I2) followed by subsequent acidic hydrolysis of (3) and (4), as a way of regiospecific transformation of picoline and isonicotine acids into their C3-halogenated derivatives, is described.