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SYNTHESIS OF 1,5-BENZODIAZEPINES
Ushirogochi, Atsuyuki,Tominaga, Yoshinori,Matsuda, Yoshiro,Kobayashi, Goro
, p. 7 - 10 (2007/10/02)
Reaction of α-oxoketene S,S-acetals (1a, b, c, d) with o-phenylenediamines gave the corresponding 1,5-benzodiazepines, 8-substituted 4-aryl-2-methylthio-3H-1,5-benzodiazepines (3a, b, c, d, e) in good yields. 2-Amino-4-aryl-8-nitro-3H-1,5-benzodiazepines (5a, b, c) were prepared by the displacement of methylthio group on compound 3b with amines (benzylamine, morpholine, 1-methylpiperazine).
