73841-80-2

Upstream product

• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 41467-26-9 1-(4-chlorophenyl)-3,3-bis(methylsulfanyl)-2-propen-1-one 
• 99-56-9 4-Nitrophenylene-1,2-diamine 
• 25755-85-5 3-(4-chlorophenyl)isoxazol-5-(4H)-one 
• 73841-76-6 2-(4-Chloro-phenyl)-4-methylsulfanyl-7-nitro-3H-benzo[b][1,4]diazepine 

Relevant academic research and scientific papers

Synthesis of 1H-1,5-benzodiazepin-2(3H)-ones from 5(4H)-isoxazolone, a heterocyclic bifunctional C-3 synthon

Unsubstituted and 7- or 8-substituted 4-aryl-1H-1,5-benzodiazepin-2(3H)-ones 3a-t have been synthesized by the condensation of 3-aryl-5(4H)-isoxazolones 1a-e and parent 4-substituted 1,2-benzenediamines 2a-d under acidic conditions.

SYNTHESIS OF 1,5-BENZODIAZEPINES

Reaction of α-oxoketene S,S-acetals (1a, b, c, d) with o-phenylenediamines gave the corresponding 1,5-benzodiazepines, 8-substituted 4-aryl-2-methylthio-3H-1,5-benzodiazepines (3a, b, c, d, e) in good yields. 2-Amino-4-aryl-8-nitro-3H-1,5-benzodiazepines (5a, b, c) were prepared by the displacement of methylthio group on compound 3b with amines (benzylamine, morpholine, 1-methylpiperazine).