73845-27-9Relevant academic research and scientific papers
Carbon-based leaving group in substitution reactions: Functionalization of sp3-hybridized quaternary and tertiary benzylic carbon centers
Mahoney, Stuart J.,Lou, Tiantong,Bondarenko, Ganna,Fillion, Eric
supporting information; experimental part, p. 3474 - 3477 (2012/09/05)
Lewis acid promoted substitution reactions employing Meldrum's acid and 5-methyl Meldrum's acid as carbon-based leaving groups are described which transform unstrained quaternary and tertiary benzylic Csp 3-Csp3 bonds into Csp3-X bonds (X = C, H, N). Importantly, this reaction has a broad scope in terms of both suitable substrates and nucleophiles with good to excellent yields obtained (typically >90%).
Reaction of carbonyl compounds with trialkylsilyl phenylselenide and tributylstannyl hydride under radical conditions
Nishiyama, Yutaka,Kajimoto, Hiroyuki,Kotani, Kazuya,Nishida, Takuma,Sonoda, Noboru
, p. 5696 - 5700 (2007/10/03)
A novel method for the hydrosilylation of carbonyl compounds has been developed. When carbonyl compounds were allowed to react with trimethylsilyl phenylselenide and tributylstannyl hydride in the presence of a catalytic amount of AIBN as the radical initiator, hydrosilylation of the carbonyl compounds efficiently proceeded to give the corresponding silyl ethers in moderate to good yields. In the absence of carbonyl compounds, the triethylsilyl hydride was obtained by the reaction of PhSeSiEt3 with Bu3SnH. Although the tributylgermyl phenylselenide instead of PhSeSiMe3 was treated with tributylstannyl hydride in the presence of a benzaldehyde under radical conditions, hydrogermylated product was not obtained and tributylgermyl hydride was mainly formed.
Ring-fluorinated pyrazoles
Bumgardner, Carl L.,Sloop, Joseph C.
, p. 141 - 146 (2007/10/02)
2-Fluoro-1,3-diketones react with phenylhydrazine to yield ring-fluorinated pyrazoles in high yield.An isoxazole is produced when 2-fluoro-1,3-diphenyl-1,3-propandione is treated with hydroxylamine hydrochloride,
Chemistry of hexamethyldisilazane. Silylation of β-diketones and amination of β-triketones
Chu, Daniel T. W.,Huckin, Stuart N.
, p. 138 - 142 (2007/10/02)
It is discovered that hexamethyldisilazane, a reagent generally used to silylate amino, hydroxyl, sulfhydryl, and carbonyl groups, reacts with β-diketones to form their trimethylsilyl enol ethers in high yield.An efficient and simple procedure for aminati
