7385-87-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
8-Bromo-naphthalen-2-ol is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of derivatives with potential therapeutic and pesticidal properties, contributing to the development of new drugs and crop protection agents.
Used in Fluorescent Polymer Preparation:
8-BROMO-NAPHTHALEN-2-OL is employed as a precursor in the preparation of fluorescent polymers. Its inherent fluorescent properties make it suitable for applications in materials science, such as the development of sensors, imaging agents, and other technologies that rely on fluorescence for detection or visualization.
Used as a Reagent in Chemical Reactions:
8-Bromo-naphthalen-2-ol serves as a versatile reagent in a variety of chemical reactions, facilitating the synthesis of complex organic molecules. Its reactivity and selectivity make it a valuable tool in the hands of chemists for advancing the synthesis of target compounds.
Used in Antimicrobial and Antifungal Applications:
Due to its antimicrobial and antifungal properties, 8-bromo-naphthalen-2-ol is considered a potential candidate for the development of new drugs and antimicrobial agents. Its ability to inhibit the growth of various microorganisms positions it as a promising component in the fight against infectious diseases and the development of novel antimicrobial therapies.

Upstream product

• 93261-69-9 8-bromo-2-benzoyloxynaphthalene 
• 118-46-7 8-amino-2-naphthol 
• 93259-50-8 p-Toluolsulfonsaeure-<8-brom-naphthyl-(2)-ester> 
• 93-44-7 2-naphthyl benzoate 
• 135-19-3 β-naphthol 
• 117294-21-0 8-bromo-2-tetralone 
• 90-11-9 1-Bromonaphthalene 
• 7385-85-5 naphthalen-2-yl tosylate 

Downstream Products

• 83710-61-6 1-bromo-7-methoxy-naphthalene 
• 144876-32-4 7-hydroxy-1-naphthaldehyde 

Relevant academic research and scientific papers

Formation of Phenalenone Skeleton by an Unusual Rearrangement Reaction

The frame rearrangement reaction of dinaphthyl ketones, possessing hydroxy groups at appropriate positions, into phenalenone derivatives under acidic conditions was discovered serendipitously. Although this rearrangement had limited scope, its mechanism was unusual, involving the division of naphthalene rings into one phenalenone ring and one benzene ring. The reaction mechanism was elucidated by direct determination of intermediate structures using 1H NMR measurements. The generated phenalenones are expected to be key intermediates toward natural products and functional materials.

Controlling the C(sp3)-C(sp2) Axial Conformation in the Enantioselective Friedel-Crafts-Type Alkylation of β-Naphthols with Inden-1-ones

The Friedel-Crafts-type reaction between properly functionalized inden-1-ones and 2-naphthols generates a hindered single bond which displays a unique preference for an antiperiplanar conformational diastereoisomer. The steric hindrance and the presence of an enantioenriched stereogenic center control the distribution of the two diastereomeric conformers at equilibrium and increase the energy for the rotation of the C(sp3)-C(sp2) single bond.

Rational molecular designs for drastic acceleration of the color-fading speed of photochromic naphthopyrans

We report rational molecular designs for acceleration of the color-fading speed of photochromic 3H-naphthopyrans. By using steric and electrostatic repulsions induced by substituents at the 2- and 10-positions of 3H-naphthopyrans, the color-fading speed accelerates from tens of minutes to microsecond time scales. The long-lived residual color, which is an important problem to be solved for industrial applications, can also be suppressed by these strategies.

COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS

Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

Synthesis and binding behavior of a Zn(II)-porphyrin having calix[5]arene cap

The synthesis and binding behavior of a Zn(II)-porphyrin having a calix[5]arene cap are presented. In order to synthesize such a bridged porphyrin, 5,15-bis(7-carboxy-1-naphthyl)-10,20-diphenylporphyrin having the syn arrangement of two naphthalene rings

ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES

Compounds of the formula wherein R1, R2, R4, R23, R24, R25 and R26 are defined as in the specification. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and antagonists.

Aryl and heteroaryl alkoxynaphthalene derivatives

Compounds of the formula wherein R1, R2, R4, R23, R24, R25 and R26 are defined as in the specification. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and antagonists.

Use of naphthalene derivatives in treating lung carcinoma

A method of inhibiting cell growth in human small cell lung carcinoma comprising administering to a mammal in need of such treatment a cell growth inhibitory amount of a compound of the formula STR1

Use of naphthalene derivatives in treating lung carcinoma

The use of a compound of the formula or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for inhibiting cell growth in human small cell lung carcinoma through inhibition of the 5HT1D receptor.