144876-32-4

Upstream product

• 158365-55-0 7-methoxynaphthalene-1-carbaldehyde 
• 2591-86-8 N-Formylpiperidine 
• 7385-87-7 8-bromo-naphthalene-2-ol 
• 6836-19-7 7-Methoxy-1-tetralone 
• 91962-80-0 (7-methoxynaphthalen-1-yl)methanol 
• 91903-17-2 7-Methoxy-naphthoesaeure-⁽¹⁾-methylester 
• 218597-21-8 methyl 7-methoxy-3,4-dihydronaphthalene-1-carboxylate 
• 135-19-3 β-naphthol 
• 3857-83-8 2-naphthyl triflate 

Relevant academic research and scientific papers

SPHENOL, A New Chiral Framework for Asymmetric Synthesis

Privileged chiral catalysts have found tremendous applications and thus immensely advanced asymmetric synthesis in the past few decades. However, truly privileged chiral frameworks are still extremely limited. Thus, the search for and development of new v

Erratum: SPHENOL, a new chiral framework for asymmetric synthesis (Journal of the American Chemical Society (2021) 143:32 (12445-12449) DOI: 10.1021/jacs.1c05709)

Page 12447. The description of the synthesis of 3,3'-diiodide 9 in the paragraph related to Scheme 4a is incorrect. The enantiopure compound 9 was obtained from SPHENOL with a methoxymethyl group as the protecting group, instead of a methyl group. The detailed procedures are provided in the updated Supporting Information. The third sentence of that paragraph, "A three-step sequence involving protection of the diol into methyl ether.", should be replaced by "A three-step sequence involving protection of the diol into methoxymethyl ether.". In footnote a of Scheme 4, "aReaction conditions: (i) NaH, MeI; (ii) nBuLi, TMEDA; I2; (iii) BBr3, DCM.", should be replaced by "aReaction conditions: (i) NaH, MOMBr; (ii) nBuLi, TMEDA, I2; (iii) HCl (6.0 M), 1,4-dioxane.".

Synthesis and reactivity of formyl-substituted photochromic 3,3- diphenyl-[3H]-naphtho[2,1-b]pyrans

Synthetic accesses to formylated photochromic 3,3-diphenyl-[3H]- naphthopyrans (or 2H-benzochromenes) are developed through classical cyclization between appropriate hydroxynaphthaldehydes and 1,1- diphenylpropyne-1-ol and also via substituent transformations on the naphthopyran skeleton including bromine/lithium exchange and the oxidation of an hydroxymethyl group. Examples of formyl group reactivity (Wittig and Knoevenagel reactions, imine formation) from these compounds are given, showing their interest in the subsequent preparation of supramolecular systems involving a photoreactive entity.

Novel frameworks for trifluoromethyl ketone and phosphonate TSA inhibitors of type II PLA2

Design and synthesis of some TSA inhibitors on novel molecular frameworks is described. This TSA analog design culminates in the preparation of the phosphonate 18.