738607-54-0Relevant academic research and scientific papers
The first example of magnesium carbenoid 1,3-CH insertion reaction: A novel method for synthesis of cyclopropanes from 1-chloroalkyl phenyl sulfoxides in high yields
Satoh, Tsuyoshi,Musashi, Jun,Kondo, Atsushi
, p. 599 - 602 (2007/10/03)
Treatment of 1-chloroalkyl phenyl sulfoxides having a geminal methyl group or a geminal benzyl group at the 2-position in THF at -78°C with isopropylmagnesium chloride gave magnesium carbenoids. Carbenoid 1,3-CH insertion reaction of the magnesium carbeno
Generation of magnesium carbenoids from 1-chloroalkyl phenyl sulfoxides with a Grignard reagent and applications to alkylation and olefin synthesis
Satoh, Tsuyoshi,Kondo, Atsushi,Musashi, Jun
, p. 5453 - 5460 (2007/10/03)
Treatment of 1-chloroalkyl phenyl sulfoxides with a Grignard reagent at low temperature gave magnesium carbenoids in quantitative yields. The generated magnesium carbenoids were found to be stable at lower than -60°C for long periods of time and are reactive with Grignard reagents to give alkylated products. The reaction of the generated magnesium carbenoids with various kinds of lithium α-sulfonyl carbanions gave olefins with carbon-carbon bond-formation in good to high yields. This method offers a good way for the preparation of olefins. The scope and limitations of the above-mentioned reactions are described.
