738607-56-2

Upstream product

• 13351-61-6 2,2-dimethyl-3-phenyl-1-propanol 
• 882-33-7 diphenyldisulfane 
• 738607-55-1 2,2-dimethyl-3-phenylpropyl phenyl sulfide 

Downstream Products

• 738607-54-0 1-chloro-2,2-dimethyl-3-phenylpropyl phenyl sulfoxide 
• 7653-94-3 1,1-dimethyl-2-phenylcyclopropane 
• 30836-86-3 1-benzyl-1-methylcyclopropane 

Relevant academic research and scientific papers

The first example of magnesium carbenoid 1,3-CH insertion reaction: A novel method for synthesis of cyclopropanes from 1-chloroalkyl phenyl sulfoxides in high yields

Treatment of 1-chloroalkyl phenyl sulfoxides having a geminal methyl group or a geminal benzyl group at the 2-position in THF at -78°C with isopropylmagnesium chloride gave magnesium carbenoids. Carbenoid 1,3-CH insertion reaction of the magnesium carbeno

Generation of magnesium carbenoids from 1-chloroalkyl phenyl sulfoxides with a Grignard reagent and applications to alkylation and olefin synthesis

Treatment of 1-chloroalkyl phenyl sulfoxides with a Grignard reagent at low temperature gave magnesium carbenoids in quantitative yields. The generated magnesium carbenoids were found to be stable at lower than -60°C for long periods of time and are reactive with Grignard reagents to give alkylated products. The reaction of the generated magnesium carbenoids with various kinds of lithium α-sulfonyl carbanions gave olefins with carbon-carbon bond-formation in good to high yields. This method offers a good way for the preparation of olefins. The scope and limitations of the above-mentioned reactions are described.