73893-33-1

Usage

Uses

Used in Pharmaceutical Industry:
4-METHYL-5,5,5-TRIFLUOROPENT-1-EN-4-OL is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Agrochemical Industry:
4-METHYL-5,5,5-TRIFLUOROPENT-1-EN-4-OL also serves as an intermediate in the production of agrochemicals, playing a role in the creation of substances that help protect and enhance crop yields.
Used in Flavor and Fragrance Industry:
4-METHYL-5,5,5-TRIFLUOROPENT-1-EN-4-OL is utilized in the formulation of flavors and fragrances, adding to the sensory characteristics of various consumer products.
Used as a Solvent in Organic Synthesis:
4-METHYL-5,5,5-TRIFLUOROPENT-1-EN-4-OL functions as a solvent in organic synthesis processes, facilitating chemical reactions and aiding in the production of desired organic compounds.
Used as a Reagent in Organic Synthesis:
Additionally, 4-METHYL-5,5,5-TRIFLUOROPENT-1-EN-4-OL is employed as a reagent in organic synthesis, participating directly in chemical reactions to form new compounds.
It is crucial to handle 4-METHYL-5,5,5-TRIFLUOROPENT-1-EN-4-OL with care due to its potential health hazards and environmental risks if mismanaged.

Upstream product

• 13891-87-7 pent-4-en-2-one 
• 75-63-8 Bromotrifluoromethane 
• 2314-97-8 iodotrifluoromethane 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 81430-05-9 2-allyl-1,2-oxaborolane 
• 1730-25-2 allylmagnesium bromide 

Downstream Products

• 73893-35-3 3-Hydroxy-3-trifluorobutyraldehyde Dimethyl acetal 

Relevant academic research and scientific papers

ORGANIC COMPOUNDS

Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as inhibitors of other enzymes characterized with a phosphotyrosine binding region such as the SH2 domain. Accordingly, the compounds of formula (I) may be employed for prevention and/or treatment of insulin resistance associated with obesity, glucose intolerance, diabetes mellitus, hypertension and ischemic diseases of the large and small blood vessels, conditions that accompany type-2 diabetes, including hyperlipidemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, irritable bowel syndrome, pancreatitis, adipose cell tumors and carcinomas such as liposarcoma, dyslipidemia, and other disorders where insulin resistance is indicated. In addition, the compounds of the present invention may be employed to treat and/or prevent cancer (such as prostate or breast cancer), osteoporosis, neurodegenerative and infectious diseases, and diseases involving inflammation and the immune system.

Allylboration of some ketones and aldehydes with 2-allyl-1,2-oxaborolane. Isolation of their intermediate adducts and synthesis of homoallylic alcohols

2-Allyl-1,2-oxaborolane (II), prepared by the reaction of 2-allyloxy-1,2-oxaborolane (I) with allylmagnesium bromide in ether, is an extremely reactive allylborane.This cyclic borinate ester II is a BCCO-type organoborane and can be used as a novel allylborating reagent.As is usual with allylboranes, II can also add smoothly to various ketones or aldehydes, and when followed by deboronation with diethanolamine gives the corresponding homoallylic alcohols IV.The adducts III, formed via a six-centre cyclic mechanism and allylic rearrangement, have been isolated and identified as a kind of 2-alkenoxy-1,2-oxaborolane.

Ultrasound-Promoted Selective Perfluoroalkylation on the Desired Position of Organic Molecules

Perfluoroalkylzinc iodides or bromides wich were prepared from perfluoroalkyl iodides or bromides and zinc powder in N,N-dimethylformamide or tetrahydrofuran with ultrasonic irradiation were found to behave as potential perfluoroalkylating reagents for the preparation of a wide variety of perfluoroalkylated compounds.Especially, the ultrasound-promoted asymmetric induction with perfluoroalkyl group on the asymmetrical carbon was achieved by the reaction of perfluoroalkyl halides with optically active enamines in the presence of zinc powder and a catalytic amount of dichlorobis(?-cyclopentadienyl)titanium.

TRIFLUOROMETHYLATION OF CARBONYL COMPOUNDS WITH TRIFLUOROMETHYLZINC IODIDE UNDER ULTRASONIC IRRADIATION

The trifluoromethylation of carbonyl compounds with trifluoromethylzinc iodide, prepared from trifluoromethyl iodide with ultrasonically dispersed zinc, smoothly proceeded to give corresponding α-trifluoromethyl carbinols in good yields.