13891-87-7Relevant academic research and scientific papers
Synthetic approaches to phomactins: Novel oxidation of homoallylic alcohols using tetra-n-propylammonium perruthenate
Blackburn, Timothy J.,Thomas, Eric J.
, p. 5399 - 5407 (2018)
Previous studies of a synthesis of phomactin A had resulted in the synthesis of a 15-methylenebicyclo[9.3.1]pentadecadiene. The next step in the synthesis was to be the epoxidation of this methylenecyclohexane that was hoped would lead to a 1-(hydroxymethyl)cyclohexene by rearrangement of the exocyclic epoxide, but the epoxidation was difficult to carry out regioselectively on advanced intermediates. However, oxidation of a 15-methylenebicyclo[9.3.1]pentadeca-3,7-dien-14-ol using tetra-n-propylammonium perruthenate and N-methylmorpholine-N-oxide led to conversion of this homoallylic alcohol into the corresponding 14-oxobicyclo[9.3.1]pentadeca-1(15),3,7-triene-15-carboxaldehyde in one step. Reduction of this using DIBAL-H gave a promising intermediate for a synthesis of a phomactin. The scope of this oxidation of homoallylic alcohols was briefly investigated.
A convenient preparation of (E)-3-penten-2-one
Chiu, Pauline,Wong, Sun Ting
, p. 4513 - 4516 (1998)
A convenient large-scale synthesis of (E)-3-penten-2-one has been described based on the synthesis of the corresponding β,γ-unsaturated ketone and its subsequent base-catalyzed olefin isomerization.
PROCESS FOR PREPARING PLATINUM ORGANOSILOXANE COMPLEXES USING AN ENONE ADDITIVE
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Paragraph 0023, (2019/02/06)
A platinum organosiloxane complex is prepared by a process including combining A) a platinous halide; B) a ketone; C) an enone additive distinct from any other starting materials or rearrangement products thereof; and D) a polyorganosiloxane having, per molecule, 2 to 4 silicon bonded terminally unsaturated hydrocarbon groups having from 2 to 6 carbon. The platinum organosiloxane complex prepared by the process is useful as a hydrosilylation catalyst.
Investigation of hollow bimetal oxide nanomaterial and their catalytic activity for selective oxidation of alcohol
Gao, Wenbin,Li, Feng,Huo, Hongfei,Yang, Yuanyuan,Wang, Xiang,Tang, Yu,Jiang, Pengbo,Li, Shuwen,Li, Rong
, p. 63 - 70 (2018/03/01)
The aerobic oxidation procedure utilized sustainable non-noble-metal catalysts has been a long-standing objective in laboratory and industrial research. The synthesized hollow bimetal oxide nanoparticles catalysts (HNPs) as a stable and efficient catalyst, which was applied to the selective oxidation of alcohols with molecular oxygen as oxidant, is reported. The catalytic performance of Co3O4/Fe3O4@C HNPs was tested via selective aerobic oxidation catalytic reaction of cinnamyl alcohol in the liquid phase. The results prove that the Co3O4/Fe3O4@C HNPs exhibit ～ 90% yield for alcohol oxidation, which can be conveniently separated and recycled from reaction system by an external magnetism. Forthrmore, the catalyst can be reutilized for at least 5 runs without a distinct activity reduction. A feasible reaction mechnism over the bimetal catalyst for the alcohol oxidation was proposed. The surface effect between metal oxide nanoparticle and carbon support, and relatively high and easy reducibility grant favorable catalytic activity of Co3O4/Fe3O4@C HNPs. This make the Co3O4/Fe3O4@C HNPs a very significant catalyst for aerobic catalytic oxidation reaction of alcohols in the liquid phase for industrial manufacture.
INHIBITION OF MACROPHAGE MIGRATION INHIBITORY FACTOR IN MELANOMA AND COLON CANCER
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Paragraph 0070, (2015/12/30)
Compounds and compositions are provided which inhibit MIF. Methods of treatment of melanoma and colon cancers are also provided.
Catalytic aerobic oxidation of allylic alcohols to carbonyl compounds under mild conditions
Tonucci, Lucia,Nicastro, Marco,D'Alessandro, Nicola,Bressan, Mario,D'Ambrosio, Primiano,Morvillo, Antonino
experimental part, p. 816 - 820 (2010/04/23)
A new catalytic aerobic oxidation of alcohols to aldehydes under green conditions was developed (room temperature and pressure, water solution, open vials). The water-soluble platinum(II) tetrasulfophthalocyanine (PtPcS) catalyst showed the best selectivity for carbonyl derivatives, and in particular for α,β-unsaturated alcohols; the reactions are slow.
Facile photochemical transformation of alkyl aryl selenides to the corresponding carbonyl compounds by molecular oxygen: Use of selenides as masked carbonyl groups
Hyugano, Takeshi,Liu, Suyou,Ouchi, Akihiko
supporting information; scheme or table, p. 8861 - 8866 (2009/04/05)
(Chemical Equation Presented) Alkyl aryl selenides with and without functional groups on the alkyl group were transformed efficiently into the corresponding carbonyl compounds, particulary primary alkyl aryl selenides in good yields, by a simple photolysis in the presence of air or oxygen. This transformation can be conducted without protection of functional groups. The yield of carbonyl compounds was much affected by the solvent viscosity, reaction temperature, concentration of dissolved oxygen in the solvents, wavelength of light, and structure of the aryl substituents. The present study indicates that aryl selenides can be considered as a masked carbonyl group that can be easily converted to a carbonyl group by very mild reaction conditions even in the presence of various unprotected functional groups. Therefore, this functional group transformation can be used as an important tool in organic synthesis due to its simplicity and mild reaction condition.
Compounds capable of activating cholinergic receptors
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, (2008/06/13)
The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.
Biocatalytic oxidative kinetic resolution of sec-alcohols: Stereocontrol through substrate-modification
Stampfer, Wolfgang,Kosjek, Birgit,Faber, Kurt,Kroutil, Wolfgang
, p. 275 - 280 (2007/10/03)
Whole lyophilised cells of Rhodococcus ruber DSM 44541 were employed for the oxidative kinetic resolution of sec-alcohols using acetone as hydrogen acceptor. The enantioselectivity of this process could be controlled effectively by introducing C-C multiple bonds into substrates, which were inefficiently recognised, in particular short-chain (ω-1)-alcohols and (ω-2)-analogs. Thus, the enantioselectivities of rac-2-pentanol (E=16.8) and rac-3-octanol (E=13.3) were significantly improved by introducing a C=C bond adjacent to the alcohol moiety to give racemic (E)-pent-3-en-2-ol and 4-(E)-octen-3-ol, which were resolved with excellent selectivities (E >100 and 50, respectively). In addition, it was found that high stereodifferentiation between the E- and Z-configured double bonds occurred, as the corresponding (Z)-isomers were not converted. Similar selectivity-enhancing effects were observed with acetylenic analogs.
Compounds capable of activating cholinergic receptors
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, (2008/06/13)
The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.
