73901-88-9Relevant academic research and scientific papers
Enantio- and Diastereodivergent Synthesis of Spirocycles through Dual-Metal-Catalyzed [3+2] Annulation of 2-Vinyloxiranes with Nucleophilic Dipoles
Huo, Xiaohong,Luo, Yicong,Peng, Youbin,Wu, Liang,Zhang, Wanbin
supporting information, p. 24941 - 24949 (2021/10/25)
The development of efficient and straightforward methods for obtaining all optically active isomers of structurally rigid spirocycles from readily available starting materials is of great value in drug discovery and chiral ligand development. However, the
Manganese-Catalyzed Ring-Opening Coupling Reactions of Cyclopropanols with Enones
Zhang, Yong-Hui,Zhang, Wen-Wei,Zhang, Ze-Yu,Zhao, Kai,Loh, Teck-Peng
supporting information, p. 5101 - 5105 (2019/07/03)
A manganese-catalyzed ring-opening coupling reaction of cyclopropanols with enones for the facile and efficient preparation of 1,6-diketones is described. A wide array of synthetically important 1,6-diketones bearing manifold functional groups are obtained with up to 93% yield. These reactions feature broad substrate scopes, environmentally benign conditions, inexpensive catalyst, and operational simplicity.
Nano CoCuFe2O4 catalyzed coupling reaction of acid chlorides with terminal alkynes: A powerful toolbox for palladium-free ynone synthesis
Matloubi Moghaddam, Firouz,Pourkaveh, Raheleh,Ahangarpour, Marzieh
, p. 71 - 75 (2017/09/08)
The present work describes the application of nano CoCuFe2O4 toward the coupling reaction of acyl chlorides with terminal alkynes. By this catalytic system, ynone derivatives were formed in high yields via a palladium-free strategy.
Double gold-catalysed annulation of indoles by enynones
Heffernan, Stephen J.,Tellam, James P.,Queru, Marine E.,Silvanus, Andrew C.,Benito, David,Mahon, Mary F.,Hennessy, Alan J.,Andrews, Benjamin I.,Carbery, David R.
, p. 1149 - 1159 (2013/05/22)
The gold-catalysed double functionalisation of indoles is presented. Enynones are used to annulate indoles via a double sodium tetrachloroaurate- catalysed process involving a mixture of C-H activation and alkyne activation modes of promotion. Good yields
Efficient methods for the preparation of acetylenic ketones
Verkruijsse, H. D.,Heus-Kloos, Y. A.,Brandsma, I.
, p. 289 - 294 (2007/10/02)
A number of acetylenic ketones RCCC(=O)R' have been obtained in good yields from lithiated acetylenes RCCLi and acetic anhydride, N,N-dimethylacetamide, or N,N-dimethylbenzamide.The most convenient and general method consists of treating alkynylzinc chlorides with acid halides R'C(=O)Cl.Benzoyl chloride (R'=Ph), acryloyl chloride (R'=CH2=CH) and butynoyl chloride (R'=C2H5CC) react only in the presence of a catalytic amount of Pd4.
AUTOOXIDATION OF ACETYLENES AND THEIR DERIVATIVES. XXV. 1-PHENYL-4-PENTEN-1-YN-3-0L AND 1-PHENYL-4-HEXEN-1-YN-3-OL
Stepin, S. G.,Tishchenko, I. G.
, p. 1771 - 1774 (2007/10/02)
During the autooxidation of secondary enynyl alcohols attack by oxygen takes place at the C-H bonds at the α position to the triple and double bonds and the hydroxyl group.The initially formed unstable hydroxyhydroperoxides dissociate under the oxidation conditions into the corresponding enynyl ketones, acetylenic keto epoxydes, and products from degradation of the carbon skeleton.
