7392-74-7

Usage

Uses

Used in Organic Synthesis:
2,3,5-Tri-O-benzoyl-2-C-methyl-D-ribonic acid-1,4-lactone is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the formation of a wide range of derivatives through chemical reactions, making it a valuable building block for the development of new molecules with potential applications in pharmaceuticals, materials science, and other industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3,5-Tri-O-benzoyl-2-C-methyl-D-ribonic acid-1,4-lactone is used as a starting material for the synthesis of novel drug candidates. Its versatile chemical structure enables the creation of new compounds with potential therapeutic properties, such as antimicrobial, antiviral, or anticancer agents. 2,3,5-Tri-O-benzoyl-2-C-methyl-D-ribonic acid-1,4-lactone's ability to form various derivatives also allows for the optimization of drug candidates to improve their efficacy, safety, and pharmacokinetic properties.
Used in Materials Science:
2,3,5-Tri-O-benzoyl-2-C-methyl-D-ribonic acid-1,4-lactone can also be utilized in the development of advanced materials with unique properties. Its potential applications in materials science include the synthesis of new polymers, coatings, or other materials with specific characteristics, such as improved stability, enhanced mechanical properties, or tailored chemical reactivity.

Upstream product

• 492-30-8 2-C-methyl-D-ribono-1,4-lactone 
• 98-88-4 benzoyl chloride 
• 93636-16-9 ethyl 2-C-methyl-DL-ribonate 
• 93635-76-8 ethyl 4,5-O-isopropylidene-2-C-methyl-DL-ribonate 
• 93714-02-4 ethyl cis-2,3-dideoxy-4,5-O-isopropylidene-2-C-methyl-DL-glycero-pent-2-enonate 
• 492-30-8 2-C-methyl-DL-ribono-1,4-lactone 
• 93635-76-8 ethyl 4,5-O-isopropylidene-2-C-methyl-DL-lyxonate 
• 492-30-8 2-C-methyl-DL-lyxono-1,4-lactone 
• 93635-76-8 ethyl 4,5-O-isopropylidene-2-C-methyl-DL-arabinonate 
• 93714-03-5 ethyl trans-2,3-dideoxy-4,5-O-isopropylidene-2-C-methyl-DL-glycero-pent-2-enonate 
• 492-30-8 2-C-methyl-DL-arabinono-1,4-lactone 

Downstream Products

• 641571-44-0 (2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(benzoyloxymethyl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate 
• 1345969-93-8 C₃₆H₃₆N₅O₁₀P 
• 205171-10-4 2,6-dichloro-9-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine 
• 30361-17-2 2-methyl-2,3,5-tribenzoyl-ribonolactol 
• 15397-15-6 1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose 
• 944476-43-1 C₂₄H₂₀N₂O₇ 
• 863329-66-2 2'-deoxy-2'-fluoro-2'-methyluridine 
• 863329-65-1 (2‘R)-2‘-deoxy-2’-fluoro-2-methyluridine-3’,5’-dibenzoate 
• 760965-38-6 C₂₉H₂₆O₉ 
• 23643-36-9 2′,3′,5′-tri-O-benzoyl-2′-C-methyluridine 
• 205171-04-6 (2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(6-chloro-9H-purin-9-yl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate 

Relevant academic research and scientific papers

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae and/or Flaviviridae viral infections with one or more nucleotide analogs.

A (2 'R) -2' - deoxy -2 '- fluoro -2' - methyl urea glucoside preparation method (by machine translation)

The invention discloses a (2 'R) -2' - deoxy -2 '- fluoro -2' - methyl urea glucoside (type I) synthetic method. Cheap and easily available starting material, through the hydroxyl protection, cyclization, the links such as fluoride, obtains the type I compound. (by machine translation)

Synthesis and Evaluation of 2,6-Modified Purine 2′-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

A variety of 2,6-modified purine 2′-C-methylribonucleosides and their phosphoramidate prodrugs were synthesized and evaluated for inhibition of HCV RNA replication in Huh-7 cells and for cytotoxicity in various cell lines. Cellular pharmacology and HCV polymerase incorporation studies on the most potent and selective compound are reported.

SYNTHESIS OF SACCHARINIC ACID DERIVATIVES

Hydroxylation of ethyl cis-2,3-dideoxy-4,5-O-isopropylidene-2-C-methyl-DL-glycero-pent-2-enonate (1) with osmium tetraoxide gave ethyl 4,5-O-isopropylidene-β-DL-galactosaccharinate (ethyl 4,5-O-isopropylidene-2-C-methyl-DL-lyxonate, 3) and ethyl 4,5-O-isopropylidene-α-DL-glucosaccharinate (ethyl 4,5-O-isopropylidene-2-C-methyl-DL-ribonate, 4).Similarly, the trans-isomer of 1 yielded a mixture of ethyl 4,5-O-isopropylidene-α-DL-galactosaccharinate (ethyl 4,5-O-isopropylidene-2-C-methyl-DL-xylonate, 5) and ethyl 4,5-O-isopropylidene-β-DL-glucosaccharinate (ethyl 4,5-O-isopropylidene-2-C-arabinonate, 6).Compounds 3-6 were transformed into the corresponding 1,4-lactones.