73966-53-7

Basic information

• Product Name: 3-[4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole
• Synonyms: EMD-23448; 3-[4-(4-Phenyl-3,4-dehydro-1-piperidyl)butyl]indole; 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indole
• CAS NO: 73966-53-7
• Molecular Formula: C₂₃H₂₆N₂
• Molecular Weight: 330.47707
• Mol File: 73966-53-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole(73966-53-7)
• EPA Substance Registry System: 3-[4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole(73966-53-7)

Safety Data

• Hazardous Substances Data: 73966-53-7(Hazardous Substances Data)

Upstream product

• 43064-12-6 1,2,3,6-tetrahydro-4-phenylpyridine hydrochloride 
• 133-32-4 4-indol-3-yl-butyric acid 
• 73966-54-8 1-<4-(3-indolyl)butanoyl>-1,2,3,6-tetrahydro-4-phenylpyridine 

Relevant articles and documents

Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1- pyridylalkyl)indoles. A novel conformational model to explain structure- activity relationships

The synthesis and dopaminergic properties of a novel type of dopamine agonist is described. The number and kind of essential structural elements differ significantly from that of the rigid apomorphine-type dopamine agonists. Using standard molecular modeling techniques, a conformational model is developed proposing a U-shaped conformation which might be energetically preferred through aromatic π-π-interactions between both of the electron rich aromatic structural elements of this class of compounds. Superimposition of conformations of the lead compound 28 with apomorphine yields a novel model explaining the atypical structure-activity relationships found in this class of indolealkylamines.