73968-17-9Relevant academic research and scientific papers
Nickel-Catalyzed Hydroamination of Olefins with Anthranils
Gao, Yang,Cui, Yushan,Huo, Yanping,Chen, Jinhong,She, Minwei,Li, Xianwei,Chen, Qian,Hu, Xiao-Qiang
, p. 12107 - 12118 (2021)
A nickel-catalyzed polarity-reversed hydroamination of olefins has been achieved with anthranils as the electrophilic aminating agents and hydrosilane as the reductant. This protocol provides a facile access to N-alkyl-2-aminobenzophenones that are versatile intermediates in organic synthesis. A wide range of olefins and anthranils are compatible in this transformation, delivering the desired amines in useful to excellent yields (38 examples, up to 92% yield). The utility of this protocol is exhibited in the late-stage functionalization of drug molecules and the valuable derivatives of the obtained amination products.
