73992-20-8

Upstream product

• 73992-15-1 benzyl<2,3β,3aβ,5,6,7,8,8aβ-octahydro-4α-methoxycarbonyl-4H-cycloheptathiophen-3α-yl>carbamic acid methyl ester 
• 66202-12-8 2aβ,4aβ,5,6,7,8,8aβ,8bβ-octahydro-2-benzyl-2H,3H-thieno<3',4',5':3,3a,4>cycloheptisoxazole 
• 66202-13-9 2,3β,3aβ,5,6,7,8,8aβ-octahydro-3α-benzylamino-4H-cycloheptathiophen-4α-ol 
• 66202-10-6 3-(2,2-diethoxyethylthio)-1-cycloheptene 
• 73992-33-3 2-<(1-cyclohepten-3-yl)thio>acetaldehyde 
• 68280-89-7 3-acetylmercaptocycloheptene 
• 36291-49-3 3-bromocycloheptene 

Relevant academic research and scientific papers

Olefinic Nitrone and Nitrile Oxide Cycloadditions. A Short Stereospecific Synthesis of Biotin from Cycloheptene

A novel synthesis of biotine (6) from cycloheptene (4) via the key amino alcohol 5 is described.The synthetic scheme is based upon an intramolecular nitrone-olefin cycloaddition of the reactive intermediate 13, generated in situ from the aldehyde

Synthesis of biotin

A novel process for the preparation of biotin is disclosed wherein said process employs inexpensive starting materials and reagents resulting in the obtention of biotin devoid of the biologically inactive stereoisomers.