74032-91-0

Upstream product

• 18992-37-5 4-nitrophenyl-2,3,4,6-tetra-O-acetyl-α-L-rhamnopyranoside 
• 100-02-7 4-nitro-phenol 
• 5160-09-8 2,3,4‐tri‐O‐acetyl-α-L‐rhamnopyranosyl chloride 
• 264610-69-7 p-nitrophenyl 2,3,4-tri-O-acetyl-α-D-fucopyranoside 
• 73-34-7 D-Fucose 
• 51921-33-6 1,2,3,4-tetra-O-acetyl-D-fucopyranose 

Downstream Products

• 183878-99-1 1-(4-aminophenoxy)-α-L-rhamnopyranoside 
• 88043-70-3 p-nitrophenyl 2,3-O-isopropylidene-α-L-rhamnopyranoside 
• 150412-46-7 p-nitrophenyl 4-O-benzyl-α-L-rhamnopyranoside 
• 150412-47-8 p-nitrophenyl 4-O-benzyl-3-O-methyl-α-L-rhamnopyranoside 
• 150412-45-6 p-nitrophenyl 4-O-benzyl-2,3-O-isopropylidene-α-L-rhamnopyranoside 
• 1053616-06-0 4-{(2S,3R,4R,5S,6S)-5-Benzyloxy-3-[(2S,3R,4R,5S,6S)-5-((2S,3R,4S,5R,6R)-3,5-bis-benzyloxy-4-methoxy-6-methoxymethyl-tetrahydro-pyran-2-yloxy)-3,4-dimethoxy-6-methyl-tetrahydro-pyran-2-yloxy]-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy}-phenylamine 
• 150424-95-6 p-nitrophenyl 4-O-benzyl-2-O-<4-O-(2,4-di-O-benzyl-3,6-O-methyl-β-D-glucopyranosyl)-2,3-di-O-methyl-α-L-rhamnopyranosyl>-3-O-methyl-α-L-rhamnopryranoside 
• 150412-54-7 p-trifluoroacetamidophenyl 4-O-benzyl-2-O-<4-O-(2,4-di-O-benzyl-3,6-O-methyl-β-D-glucopyranosyl)-2,3-di-O-methyl-α-L-rhamnopyranosyl>-3-O-methyl-α-L-rhamnopryranoside 
• 114284-03-6 p-nitrophenyl 4-O-(3,6-di-O-acetyl-2,4-di-O-benzyl-α-D-glucopyranosyl)-2,3-O-isopropylidene-α-L-rhamnopyranoside 
• 88043-73-6 p-trifluoroacetamidophenyl 4-O-α-D-glucopyranosyl-α-L-rhamnopyranoside 
• 88043-71-4 p-nitrophenyl 2,3-O-isopropylidene-4-O-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-α-L-rhamnopyranoside 
• 88043-72-5 p-trifluoroacetamidophenyl 2,3-O-isopropylidene-4-O-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-α-L-rhamnopyranoside 
• 86795-37-1 p-nitrophenyl 2-O-acetyl-4-O-benzyl-α-L-rhamnopyranoside 
• 86795-41-7 p-aminophenyl 2-O-acetyl-3-O-α-L-rhamnopyranosyl-α-L-rhamnopyranoside 

Relevant academic research and scientific papers

Synthesis of aryl α-O-L-rhamnopyranoside by two-step reaction in one pot

The title compounds were conveniently synthesized by a phase transfer catalyzed approach in two steps and one pot using the rhamnopyranosyl chloride as key intermediate. The twostep one-pot procedure is more convenient and environmentally friendly, compared to the published synthetic routes. Besides, the structure-reactivity relationship and the plausible mechanism for this base-catalyzed glycosylation were discussed bymeans of the Hammett equation.

Hydrolytic activity of α-galactosidases against deoxy derivatives of p- nitrophenyl α-D-galactopyranoside

The four possible monodeoxy derivatives of p-nitrophenyl (PNP) α-D- galactopyranoside were synthesized, and hydrolytic activities of the α- galactosidase of green coffee bean, Mortierella vinacea and Aspergillus niger against them were elucidated. The 2- and 6-deoxy substrates were hydrolyzed by the enzymes from green coffee bean and M. vinacea, while they scarcely acted on the 3- and 4-deoxy compounds. On the other hand, A. niger α- galactosidase hydrolyzed only the 2-deoxy compound in these deoxy substrates, and the activity was very high. These results indicate that the presence of two hydroxyl groups (OH-3 and -4) is essential for the compounds to act as substrates for the enzymes of green coffee bean and M. vinacea, while the three hydroxyl groups (OH-3, -4, and -6) are necessary for the activity of the A. niger enzyme. The kinetic parameters (K(m) and V(max)) of the enzymes for the hydrolysis of PNP α-D-galactopyranoside and its deoxy derivatives were obtained from kinetic studies. (C) 2000 Elsevier Science Ltd.