74073-22-6

Basic information

• Product Name: Methyl 2-(2,3-dichlorobenzylidine)acetoacetate
• Synonyms: METHYL-2-(2,3-DICHLORBENZYLIDEN)-ACETOACETATE;2,3-Dichlorobenzylideneaceto;METHYL 2-(2,3-DICHLOROBENZYLIDINE)ACETOACETATE;2-[(2,3-Dichlorophenyl)methylene]-3-oxobutanoic acid methyl ester;BUTANOICACID,2-[(2,3-DICHLOROPHENYL)METHYLENE]-3-OXO-,METHYLESTER(9CI);2-nitro-4-methylsulfonyl benzoyl chloride;Methyl 2-(2,3-dichlo;Methyl 2-(2,3-Dichlorobenzylidene)acetoacetate
• CAS NO: 74073-22-6
• Molecular Formula: C₁₂H₁₀Cl₂O₃
• Molecular Weight: 273.11
• EINECS: 1312995-182-4
• Product Categories: Aromatics;Intermediates
• Mol File: 74073-22-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 81-83 °C
• Boiling Point: 383.6 °C at 760 mmHg
• Flash Point: 157.1 °C
• Appearance: /
• Density: 1.337
• Vapor Pressure: 4.35E-06mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Methyl 2-(2,3-dichlorobenzylidine)acetoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(2,3-dichlorobenzylidine)acetoacetate(74073-22-6)
• EPA Substance Registry System: Methyl 2-(2,3-dichlorobenzylidine)acetoacetate(74073-22-6)

Safety Data

• Hazardous Substances Data: 74073-22-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 74073-22-6 differently. You can refer to the following data:
1. Methyl 2-(2,3-dichlorobenzylidine)acetoacetate is an intermediate,it is used in the preparation of dihydropyridine calcium antagonists.
2. An intermediate used in the preparation of dihydropyridine calcium antagonists.

InChI:InChI=1/C12H10Cl2O3/c1-7(15)9(12(16)17-2)6-8-4-3-5-10(13)11(8)14/h3-6H,1-2H3/b9-6+

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 6334-18-5 2,3-dichlorobenzylaldehyde 

Downstream Products

• 72509-76-3 ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate 
• 123853-39-4 (+)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid 
• 74073-26-0 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate-(tert-butyl) methylester 
• 101411-53-4 4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-2-(2-hydroxyethoxymethyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 110962-94-2 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate methyl ester-(2-cyanoethyl)ester 
• 96918-80-8 cyclopropylmethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 

Relevant articles and documents

An efficient and recyclable 3D printed α-Al2O3 catalyst for the multicomponent assembly of bioactive heterocycles

A catalytic methodology is reported that enables the efficient, operationally simple and environmentally friendly synthesis of diverse 1,4-dihydropyridines and 3,4-dihydropyrimidin-2(1H)-ones, including some relevant drugs and pharmacologically active derivatives. This strategy is based on the use of a 3D printed Al2O3 woodpile material that was sintered to generate a rigid structure with controlled porosity and noteworthy catalytic performance. The 3D printed Al2O3 catalyst exhibits remarkable efficacy as a Lewis acid in Biginelli and Hantzsch reactions and it can be recovered and reused ten times without any decrease in the activity. Remarkable E factors, excellent recyclability and scalability, broad substrate scope, short reaction times, excellent yields, solvent-free conditions and easy isolation procedures are key features of this methodology.