741-90-2Relevant academic research and scientific papers
Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase
Baugh, Simon D.P.,Jackson, Michael R.,Rashad, Adel Ahmed,Reitz, Allen B.,Lam, Patrick Y.S.,Jorns, Marilyn Schuman
supporting information, (2021/11/20)
Here we report the first small-molecule inhibitors of human sulfide:quinone oxidoreductase (SQOR) that decrease the rate of breakdown of hydrogen sulfide (H2S), a potent cardioprotective signaling molecule. SQOR is a mitochondrial membrane-boun
COMPOUNDS AND METHODS FOR TREATING OR PREVENTING HEART FAILURE
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Page/Page column 104; 126-127; 131-132, (2020/07/25)
The present invention relates to the discovery of novel compounds that can be used to treat and/or prevent heart failure in a subject. In certain embodiments, the compounds of the invention are sulfide: quinone oxidoreductase (SQOR) inhibitors. In other e
