110860-92-9

Basic information

• Product Name: 2,3-Dichloro-5-hydroxypyridine
• Synonyms: 2,3-DICHLORO-5-HYDROXYPYRIDINE;5,6-Dichloro-3-hydroxypyridine;3-Dichloro-5-hydroxypyridine;3-Pyridinol,5,6-dichloro-
• CAS NO: 110860-92-9
• Molecular Formula: C₅H₃Cl₂NO
• Molecular Weight: 163.99
• Product Categories: Boronic Acid;Heterocycle-Pyridine series
• Mol File: 110860-92-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 184.0 to 188.0 °C
• Boiling Point: 365.5 °C at 760 mmHg
• Flash Point: 174.8 °C
• Appearance: /
• Density: 1.561 g/cm³
• Vapor Pressure: 7.45E-06mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.91±0.10(Predicted)
• CAS DataBase Reference: 2,3-Dichloro-5-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dichloro-5-hydroxypyridine(110860-92-9)
• EPA Substance Registry System: 2,3-Dichloro-5-hydroxypyridine(110860-92-9)

Safety Data

• Hazardous Substances Data: 110860-92-9(Hazardous Substances Data)

Usage

General Description

2,3-Dichloro-5-hydroxypyridine is a chemical compound that belongs to the class of compounds known as dichlorobenzenes. Dichlorobenzenes are organochlorine compounds with a benzene ring substituted by two chlorine atoms. This particular compound is characterized by the presence of a pyridine ring, which is a six-membered aromatic ring with one nitrogen atom, substituted with two chlorine atoms and one hydroxyl group. It is primarily used in the industry as an intermediate in the synthesis of other complex organic compounds. The presence of chlorine atoms makes this compound reactive, and the hydroxyl group can take part in various chemical reactions, further increasing its reactivity and versatility.

InChI:InChI=1/C5H3Cl2NO/c6-4-1-3(9)2-8-5(4)7/h1-2,9H

Upstream product

• 98121-41-6 5-Amino-2,3-dichloropyridine 
• 22353-38-4 3-chloro-2-hydroxy-5-nitropyridine 
• 22353-40-8 2,3-dichloro-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 110861-18-2 5-acetoxy-2,3-dichloropyridine 
• 74115-12-1 5-chloropyridin-3-ol 

Downstream Products

• 1654021-72-3 ((5,6-dichloro-2-cyanopyridin-3-yl)oxy)acetic acid ethyl ester 

Relevant articles and documents

PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

Multi-gram synthesis of a nucleotide-competing reverse transcriptase inhibitor

An efficient multi-gram synthesis of a nucleotide-competing reverse transcriptase inhibitor is reported. The synthesis features a chiral auxiliary-assisted alcohol resolution, a Mitsunobu reaction involving a carbamate, followed by a lithium-iodide exchange/Weinreb ketone synthesis tandem. These chemical transformations were optimized in order to increase the yield of the synthesis. The route is concluded by a late-stage palladium-catalyzed cyanation followed by a pyrimidine-2-one ring formation.

3-Pyridyl enantiomers and their use as analgesics

The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: STR1 or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.