741687-07-0

Basic information

• Product Name: 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE
• Synonyms: 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE;1-Piperidinecarboxylicacid,4-amino-4-ethyl-,1,1-dimethylethylester(9CI);tert-butyl 4-amino-4-ethylpiperidine-1-carboxylate;1-Boc-4-aMino-4-ethylpiperidine;4-Amino-4-ethyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-amino-4-ethyl-, 1,1-dimethylethyl ester
• CAS NO: 741687-07-0
• Molecular Formula: C₁₂H₂₄N₂O₂
• Molecular Weight: 228.33116
• Product Categories: ETHYL
• Mol File: 741687-07-0.mol

Chemical Properties

• Boiling Point: 300.561 °C at 760 mmHg
• Flash Point: 135.575 °C
• Appearance: /
• Density: 1.000
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE(741687-07-0)
• EPA Substance Registry System: 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE(741687-07-0)

Safety Data

• Hazardous Substances Data: 741687-07-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE serves as a key intermediate in the synthesis of various pharmaceuticals. Its presence in the molecular structure of target compounds is crucial for achieving desired therapeutic effects, such as modulating biological pathways or interacting with specific receptors.
Used in Organic Synthesis:
In the field of organic synthesis, 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE is utilized as a versatile building block for creating a wide range of organic compounds. Its unique functional groups and structural features facilitate the formation of diverse chemical entities with potential applications in various industries.
Used in Drug Discovery:
4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE is employed in drug discovery processes to identify and develop new therapeutic agents. Its incorporation into novel molecular frameworks can lead to the discovery of compounds with improved pharmacological properties, such as enhanced potency, selectivity, and reduced side effects.
Used in Medicinal Chemistry Research:
In medicinal chemistry research, 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE is used as a structural motif to explore the structure-activity relationships of potential drug candidates. Its introduction into different chemical scaffolds allows researchers to investigate the impact of specific structural modifications on the biological activity and pharmacokinetic profile of the resulting compounds.

InChI:InChI=1/C12H24N2O2/c1-5-12(13)6-8-14(9-7-12)10(15)16-11(2,3)4/h5-9,13H2,1-4H3

Upstream product

• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 1207178-24-2 tert-butyl 4-cyano-4-ethylpiperidine-1-carboxylate 
• 188792-67-8 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid 
• 578021-55-3 1-tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 

Relevant articles and documents

PIPERIDINE DERIVATIVES AS HDAC1/2 INHIBITORS

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDACl and/or HDAC2 activity.

NOVEL PIPERIDINE/8-AZABICYCLO [3.2.1] OCTAN DERIVATIVES AS MODUILATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein neither R4 nor R5 is hydrogen; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists

4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopiperidine derivatives was described, employing isonipecotate as a starting material and Curtius rearrangement as a key step. The alkylation of isonipecotate could introduce various substituents at the 4-position of the piperidine ring. With this key building block, we are able to efficiently synthesize piperazino-piperidine based CCR5 antagonist in a highly convergent manner free of using toxic reagents such as diethylaluminum cyanide. The concise synthesis of a potent bioavailable CCR5 antagonist as HIV-1 entry inhibitor, Sch-350634 (1) was accomplished in excellent yield using N′-Boc-4-methyl-4-aminopiperidine 5a as a smart building block. The new methodology provides a facile and practical access to the piperazino-piperidine amide analogs as HIV-1 entry inhibitors.