188792-67-8

Usage

Uses

Used in Pharmaceutical Synthesis:
1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID is used as a key intermediate for the synthesis of various pharmaceuticals, leveraging its structural properties to facilitate the creation of new drug molecules.
Used in Agrochemical Production:
In the agrochemical industry, 1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID is utilized as a precursor in the development of compounds designed to protect crops and enhance agricultural productivity.
Used in Organic Chemistry Research:
1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID is employed as a ligand in metal-catalyzed reactions, contributing to advancements in organic synthesis and the discovery of novel chemical processes.
Used in Chemical Compound Production:
1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID serves as an essential building block in the production of a variety of chemical compounds, highlighting its versatility and importance in the chemical industry.

Upstream product

• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1126-09-6 4-carbethoxypiperidine 
• 188792-70-3 ethyl 1-boc-4-ethyl-4-piperidine carboxylate 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 578021-55-3 1-tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate 

Downstream Products

• 1227465-48-6 4-ethylpiperidine-4-carboxylic acid 
• 872850-48-1 tert-butyl 4-isocyanato-4-methylpiperidine-1-carboxylate 
• 741687-07-0 tert-butyl 4-amino-4-ethylpiperidine-1-carboxylate 
• 885523-41-1 1-boc-4-ethyl-4-formylpiperidine 
• 1428478-56-1 1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate 

Relevant academic research and scientific papers

Small molecule compound

The invention provides a small molecule compound. The small molecule compound is characterized in that the small molecule compound is a compound shown in a structural formula in the specification, ora stereoisomer, a geometric isomer, a tautomer, a racemate, a hydrate, a solvate, a metabolite, and a pharmaceutically acceptable salt or pro-drug thereof, wherein X1 and X2 are selected from carbon or nitrogen; Z is carbon or nitrogen; n1 is 0 and 1; n2 and n3 are the same or different, and are 0 or any natural numbers; a cyclic group represented by G is a saturated heterocyclic ring; any one orseveral hydrogen atoms on the saturated heterocyclic ring are substituted by R; and R is selected from hydrogen, halogen, alkyl, substituted alkyl, amino, amine group, substituted amine group, carboxyl, amido, substituted amido, ester group, substituted carbonyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, substituted sulfonyl, and substituted sulfoxide group. The small molecule compound of the invention can be used to treat, prevent and alleviate autoimmune diseases and/or immune-related inflammatory skin diseases.

LUPEOL-TYPE TRITERPENE DERIVATIVES AS ANTIVIRALS

The invention relates to novel lupeol-type triterpene derivatives and related compounds, and pharmaceutical compositions useful for therapeutic treatment of viral diseases and particularly HIV mediated diseases.

Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists

4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopiperidine derivatives was described, employing isonipecotate as a starting material and Curtius rearrangement as a key step. The alkylation of isonipecotate could introduce various substituents at the 4-position of the piperidine ring. With this key building block, we are able to efficiently synthesize piperazino-piperidine based CCR5 antagonist in a highly convergent manner free of using toxic reagents such as diethylaluminum cyanide. The concise synthesis of a potent bioavailable CCR5 antagonist as HIV-1 entry inhibitor, Sch-350634 (1) was accomplished in excellent yield using N′-Boc-4-methyl-4-aminopiperidine 5a as a smart building block. The new methodology provides a facile and practical access to the piperazino-piperidine amide analogs as HIV-1 entry inhibitors.

Amide compounds and use of the same

An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like, R5