7417-20-1

Usage

Uses

Used in Synthetic Chemistry:
2-(3,5-DIMETHOXYPHENYL)ETHANOL is used as a chemical intermediate for the synthesis of more complex chemicals. Its role in synthetic chemistry is significant due to its ability to participate in various organic reactions, making it a valuable component in the creation of new compounds.
Used in Esterification Reactions:
In esterification processes, 2-(3,5-DIMETHOXYPHENYL)ETHANOL is used as a reactant to form esters, which are important in the production of fragrances, flavors, and other chemical products.
Used in Oxidation Reactions:
2-(3,5-DIMETHOXYPHENYL)ETHANOL is employed in oxidation reactions, where it can be transformed into other compounds with different functional groups, expanding its utility in chemical synthesis.
Used in Reduction Reactions:
2-(3,5-DIMETHOXYPHENYL)ETHANOL is also used in reduction reactions, allowing for the conversion of certain functional groups to simpler forms, which can be crucial in the synthesis of specific target molecules.
Used in Pharmaceutical Industry:
2-(3,5-DIMETHOXYPHENYL)ETHANOL is used as a building block in the development of pharmaceutical compounds, contributing to the creation of new drugs with potential therapeutic applications.
Used in Flavor and Fragrance Industry:
In the flavor and fragrance industry, 2-(3,5-DIMETHOXYPHENYL)ETHANOL is used as a key component in the formulation of various scents and tastes, capitalizing on its ability to undergo esterification and other reactions to produce desired aromatic profiles.

InChI:InChI=1/C10H14O3/c1-12-9-5-8(3-4-11)6-10(7-9)13-2/h5-7,11H,3-4H2,1-2H3

Upstream product

• 4670-10-4 (3,5-dimethoxyphenyl)acetic acid 
• 65976-77-4 (3,5-dimethoxy-phenyl)-acetic acid ethyl ester 
• 83638-28-2 2-<2'-(3,5-dimethoxyphenyl)ethoxy>-2H-tetrahydropyran 
• 6512-32-9 methyl 2-(3,5-dimethoxyphenyl)acetate 
• 67-56-1 methanol 
• 877-88-3 3,5-dimethoxybenzyl bromide 
• 26050-72-6 (3,5-dimethoxybenzyl)trimethylammonium chloride 
• 17213-59-1 2-diazo-1-(3,5-dimethoxyphenyl)ethanone 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 6652-32-0 3,5-dimethoxybenzylchloride 
• 13388-75-5 3,5-dimethoxyphenylacetonitrile 

Downstream Products

• 37567-80-9 1-(2-bromoethyl)-3,5-dimethoxybenzene 
• 34155-94-7 3,5-dimethoxyphenethyl tosylate 
• 68945-68-6 2-(2-Benzyloxy-ethyl)-6-methoxy-[1,4]benzoquinone 
• 154821-87-1 Acetic acid 3,6-diacetoxy-2-(2-hydroxy-ethyl)-4-methoxy-phenyl ester 
• 154821-85-9 Acetic acid 3,6-diacetoxy-2-(2-bromo-ethyl)-4-methoxy-phenyl ester 
• 154821-84-8 Acetic acid 3,6-diacetoxy-2-(2-benzyloxy-ethyl)-4-methoxy-phenyl ester 
• 154821-83-7 Acetic acid 3,6-diacetoxy-2-[2-(dimethoxy-phosphoryl)-ethyl]-4-methoxy-phenyl ester 
• 97025-47-3 2-<β-(3,5-Dimethoxy-phenyl)-aethyl>-malonsaeure 
• 171290-52-1 1-Ethynyl-3,5-dimethoxy-benzene 

Relevant academic research and scientific papers

Stereoselective Total Synthesis of (-)-(2 S,4 R)-3′-Methoxyl Citreochlorol: Preparation and Use of New Proline-Based Auxiliary for Asymmetric Acetate Aldol Reaction

The first stereoselective total synthesis of (-)-(2S,4R)-3′-methoxy citreochlorol and (-)-(2S,4S)-3′-methoxy citreochlorol is demonstrated. A proline-based imidazolidinone was synthesized and used as chiral auxiliary for asymmetric acetate aldol reaction to generate initial chirality in the targeted molecule. Geminal dichloromethane functionality was introduced by the addition of in situ generated dichloromethyllithium to Weinreb's amide functional group.

A concise approach to anthraquinone-xanthone heterodimers

A synthetic approach to anthraquinone-xanthone heterodimers is described. The route to the pentacyclic core features an efficient assembly of a benzocycloheptenone via a new intramolecular oxidative arylation of an enol ether and a Hauser-Kraus annulation-aldol reaction sequence to access the characteristic bicyclo[3.2.2]nonene motif. Acremoxanthone A is synthesized in 10 steps from commercially available material to demonstrate the application of this approach.

ONO-pincer ruthenium complex-bound norvaline for efficient catalytic oxidation of methoxybenzenes with hydrogen peroxide

The enhanced catalytic activity of ruthenium complex-bound norvaline Boc-l-[Ru]Nva-OMe 1, in which the ONO-pincer ruthenium complex Ru(pydc)(terpy) 2 is tethered to the α-side chain of norvaline, has been demonstrated for the oxidation of methoxybenzenes to p-benzoquinones with a wide scope of substrates and unique chemoselectivity.

Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability

Cannabidiol is the nonpsychoactive natural component of C. sativa that has been shown to be neuroprotective in multiple animal models. Our interest is to advance a therapeutic candidate for the orphan indication hepatic encephalopathy (HE). HE is a serious neurological disorder that occurs in patients with cirrhosis or liver failure. Although cannabidiol is effective in models of HE, it has limitations in terms of safety and oral bioavailability. Herein, we describe a series of side chain modified resorcinols that were designed for greater hydrophilicity and "drug likeness", while varying hydrogen bond donors, acceptors, architecture, basicity, neutrality, acidity, and polar surface area within the pendent group. Our primary screen evaluated the ability of the test agents to prevent damage to hippocampal neurons induced by ammonium acetate and ethanol at clinically relevant concentrations. Notably, KLS-13019 was 50-fold more potent and >400-fold safer than cannabidiol and exhibited an in vitro profile consistent with improved oral bioavailability.

NOVEL FUNCTIONALIZED 1,3-BENZENE DIOLS AND THEIR METHOD OF USE FOR THE TREATMENT OF HEPATIC ENCEPHALOPTHY

Pharmaceutical compositions of the invention include novel functionalized 1,3-benzenediols having a disease-modifying action in the treatment of hepatic encephalopathy and related conditions. Pharmaceutical compositions of the invention further include novel neuroprotective agents.

NOVEL FUNCTIONALIZED 1,3-BENZENE DIOLS AND THEIR METHOD OF USE FOR THE TREATMENT OF HEPATIC ENCEPHALOPATHY

Pharmaceutical compositions of the invention include novel functionalized 1,3-benzenediols having a disease-modifying action in the treatment of hepatic encephalopathy and related conditions. Pharmaceutical compositions of the invention further include novel neuroprotective agents.

Catalytic Cyclization of o-Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3-Benzazepines

A novel osmium-catalyzed cyclization of o-alkynyl phenethylamines to give 3-benzazepines is reported. The procedure allows the straightforward preparation of a broad range of dopaminergic 3-benzazepine derivatives. Mechanistic investigations revealed that the process takes place via osmacyclopropene intermediates, which were isolated and characterized by X-ray crystallography.

Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP)

N-Myristoyltransferase (NMT) is an essential eukaryotic enzyme and an attractive drug target in parasitic infections such as malaria. We have previously reported that 2-(3-(piperidin-4-yloxy)benzo[b]thiophen-2-yl)-5-((1,3, 5-trimethyl-1H-pyrazol-4-yl)meth

NOVEL COMPOUNDS AND THEIR USE IN THERAPY

The invention provides compounds which inhibit N-myristoyltransferase and are selective for protozoal N-myristoyltransferase and, consequently suitable to treat microbial infections, including viral and fungal infections, and protozoan infections such as malaria, leishmaniasis and sleeping sickness.

A straightforward diastereoselective synthesis and evaluation of climacostol, a natural product with anticancer activities

On the basis of continued interest in plant-derived natural products as anticancer agents, a shorter and more efficient synthesis of climacostol is reported. This compound showed an anticancer activity better than that of the natural product. The improved