741705-70-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Piperidineacetic acid, a-phenyl-, hydrochloride, (aR,2R)is used as a key intermediate in the synthesis of various pharmaceuticals for the treatment of anxiety, depression, and neurodegenerative disorders. Its central nervous system stimulant properties make it a promising candidate for therapeutic agents in these areas.
Used in Research and Development:
In the pharmaceutical industry, 2-Piperidineacetic acid, a-phenyl-, hydrochloride, (aR,2R)is utilized in research and development to explore its potential as a therapeutic agent for neurological and psychiatric disorders. Preclinical studies have shown promise in its efficacy, further driving its use in the development of novel treatments.

Upstream product

• 160707-37-9 d-threo-2-phenyl-2-(piperidine-2-yl)acetamide 
• 1076192-92-1 2-phenyl-2-(piperidin-2-yl)acetic acid 
• 1556855-36-7 d-threo ritalinic acid dibenzoyl-L-tartrate 

Downstream Products

• 159701-30-1 C₁₃⁽¹¹⁾CH₁₉NO₂ 
• 19262-68-1 dexmethylphenidate hydrochloride 
• 741702-87-4 d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl ethanoic acid chloride 

Relevant academic research and scientific papers

AN IMPROVED PROCESS FOR - THE PREPARATION OF DEXMETHYLPHENIDATE HYDROCHLORIDE.

The present invention relates to an improved process for the preparation of Dexmethylphenidate hydrochloride of formula (A). More particularly, the present invention relates to an improved process for the preparation of Dexmethylphenidate hydrochloride of formula (A) and its intermediate d-threo ritalinic acid hydrochloride of formula (III).

IMPROVED PROCESS FOR THE PREPARATION OF D-THREO-RITALINIC ACID HYDROCHLORIDE BY RESOLUTION OF DL-THREO-RITALINIC ACID USING CHIRAL CARBOXYLIC ACID

The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-ritalinic acid using a chiral carboxylic acid The d-threo-ritalinic acid hydrochloride prepared by the process of the present invention on esterif?cation gives d-threo-methylphenidate, a very well known CNS stimulant.

METHOD FOR THE PRODUCTION OF D-THREO-2-PHENYL-2-PIPERIDINE-2-YL ACETATES

Disclosed is a method for producing d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl acetate and the acid addition salts thereof by converting d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl ethanoic acid or an acid addition salt thereof into the corresponding