74175-13-6

Usage

Uses

Used in Agricultural Industry:
4-[(3-chloropropanoyl)amino]phenylarsonic acid is used as a post-emergent herbicide for controlling broadleaf weeds in various crops. It functions by inhibiting the enzyme acetohydroxyacid synthase (AHAS), which plays a crucial role in the biosynthesis of branched-chain amino acids in plants. The disruption of this enzyme leads to the impaired growth and eventual death of the affected plants.
However, it is essential to handle and use 4-[(3-chloropropanoyl)amino]phenylarsonic acid with caution due to its toxicity to humans and animals. Additionally, proper management is required to minimize potential environmental risks associated with its use.

Upstream product

• 98-50-0 p-aminophenylarsonic acid 
• 625-36-5 2-chloropropionyl chloride 

Relevant academic research and scientific papers

Dual Inhibition of Pyruvate Dehydrogenase Complex and Respiratory Chain Complex Induces Apoptosis by a Mitochondria-Targeted Fluorescent Organic Arsenical in vitro and in vivo

Based on the potential therapeutic value in targeting mitochondria and the fluorophore tracing ability, a fluorescent mitochondria-targeted organic arsenical PDT-PAO-F16 was fabricated, which not only visualized the cellular distribution, but also exerted anti-cancer activity in vitro and in vivo via targeting pyruvate dehydrogenase complex (PDHC) and respiratory chain complexes in mitochondria. In details, PDT-PAO-F16 mainly accumulated into mitochondria within hours and suppressed the activity of PDHC resulting in the inhibition of ATP synthesis and thermogenesis disorder. Moreover, the suppression of respiratory chain complex I and IV accelerated the mitochondrial dysfunction leading to caspase family-dependent apoptosis. In vivo, the acute promyelocytic leukemia was greatly alleviated in the PDT-PAO-F16 treated group in APL mice model. Our results demonstrated the organic arsenical precursor with fluorescence imaging and target-anticancer efficacy is a promising anticancer drug.

A mitochondria-targeted organic arsenical accelerates mitochondrial metabolic disorder and function injury

Considering the vital role of mitochondria in the anti-cancer mechanism of organic arsenical, the mitochondria-targeted precursor PDT-PAO-TPP was designed and synthesized. PDT-PAO-TPP, as a delocalization lipophilic cation (DLCs) which mainly accumulated