7418-70-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloropyridine-3-carboxamide is used as a key intermediate in the synthesis of various drugs. Its reactivity allows for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Industry:
This chemical compound is also utilized as an intermediate in the production of agrochemicals, such as pesticides. Its properties enable the creation of effective pest control agents to protect crops and enhance agricultural productivity.
Used in Organic Chemistry Research:
4-Chloropyridine-3-carboxamide serves as a valuable building block in organic chemistry research. Its versatile reactivity allows scientists to explore new chemical reactions and synthesize novel organic compounds with potential applications in various fields.

InChI:InChI=1/C6H5ClN2O/c7-5-1-2-9-3-4(5)6(8)10/h1-3H,(H2,8,10)

Upstream product

• 98-92-0 nicotinamide 
• 89284-61-7 4-chloro-nicotinonitrile 
• 100191-53-5 3-carboxy-4-chloropyridine hydrochloride 
• 10177-29-4 4-chloronicotinic acid 

Downstream Products

• 1446357-58-9 2-phenyl-4H-pyrido[3,4-e][1,3]oxazin-4-one 
• 1429746-90-6 4-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-5-hydroxypyrimidin-4-yl}amino)pyridine-3-carboxamide 

Relevant academic research and scientific papers

Method for preparing amide compounds by using supported metal oxide catalytic material

The invention relates to a catalyst for preparing amide compounds, and aims to provide a method for preparing amide compounds by using a supported metal oxide catalytic material. The method comprisesthe following steps: uniformly mixing a solvent, water, an organic nitrile compound and the catalytic material; performing a reaction at 50-180 DEG C for 0.5-48 h; and hydrating and converting the organic nitrile compound into the corresponding amide compounds through the catalytic hydration effect of the catalyst in the reaction process. Adsorption and activation of the catalytic material to water molecules can be effectively regulated by regulating metal components loaded on the catalytic material and a catalytic material carrier, so that important amide compounds in chemical and agricultural processes are efficiently prepared. The provided method for preparing the amide compounds is effect, and has the advantages of high atom utilization rate in the reaction process, low reaction temperature, no additional reaction assistant in the synthesis process, no generation of toxic or harmful byproducts after the reaction, and green and environment-friendly synthesis process.

Raf inhibitor compounds and methods of use thereof

Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

FUSED FURAN COMPOUND

The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and , R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

A new redox system: Trichloromethylarene - Pyridine base. On the mechanism of the synthesis of N-(4-pyridyl)pyridinium dichloride

A redox reaction of trichloromethylarenes with pyridines results in respective N-(α-chloroarylmethyl)-substituted pyridinium chlorides which give on hydrolysis aromatic aldehydes and 4-chloropyridines or 1,4'- bipyridinium salts.

11a-Methano-TXA compounds

The present invention provides novel 11a-methano-TXA compounds and intermediates and processs for their preparation. Further provided are methods for using these novel TXA analogs as inhibitors of thromboxane synthetase, rendering these analogs useful for a variety of pharmacological purposes. These pharmacological uses include anti-inflammatory, anti-thromobitc, and anti-asthma indications.