74185-41-4

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 40899-71-6 1-benzenesulfonylindole 
• 120-72-9 indole 
• 74185-40-3 Methyl 2-(1-benzenesulfonylindol-2-yl)-2-hydroxypropionate 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 75400-66-7 N-(phenylsulfonyl)-2-methoxalylindole 

Downstream Products

• 74185-47-0 Methyl 2-(1-benzenesulfonyl-2-indolyl)-propionate 
• 74185-45-8 (1R,4R,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid dimethyl ester 
• 74195-04-3 (1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid dimethyl ester 
• 79328-92-0 (1R,4R,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-tert-butyl ester 6-methyl ester 
• 79328-87-3 (1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-tert-butyl ester 6-methyl ester 
• 79328-95-3 methyl 7-exo-(1-phenylsulfonylindol-2-yl)-2-azabicyclo[2.2.2]oct-5-ene-7-endo-carboxylate 
• 108713-16-2 methyl 2-<(benzyloxy)carbonyl>-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>oct-7-ene-6-endo-carboxylate 
• 79328-88-4 methyl 2-(benzyloxycarbonyl)-7-exo-(1-phenylsulfonylindol-2-yl)-2-azabicyclo[2.2.2]oct-5-ene-7-endo-carboxylate 
• 79328-90-8 (1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 6-methyl ester 2-(2,2,2-trichloro-ethyl) ester 

Relevant academic research and scientific papers

Synthesis and Reactions of N-Protected 2-Lithiated Pyrroles and Indoles. The tert-Butoxycarbonyl Substituent as a Protecting Group

N-(tert-Butoxycarbonyl)pyrrole and N-(tert-butoxycarbonyl)indole have been prepared and lithiated at the 2-position with lithium 2,2,6,6-tetramethylpiperidide and tert-butyllithium, respectively.These lithium reagents react with a variety of electrophiles to give the 2-substituted N-(tert-butoxycarbonyl)pyrroles and N-(tert-butoxycarbonyl)indoles.The N-(tert-butoxycarbonyl) substituent may be removed rapidly and in high yield from the pyrrole derivatives under basic conditions.For the indole derivatives, the protecting group may be removed with either acidic or basic conditions.

Chloroacetamide Photocyclization. Synthesis of 20-Deethylcatharanthine

20-Deethylcatharanthine, a potential precursor of vinblastine-type dimeric indole alkaloids, has been synthesized in ten steps from 1-benzenesulfonylindole.The Synthesis features a Diels-Alder reaction between 1-carbethoxy-1,2-dihydropyridine and ethyl 2-