74185-81-2

Basic information

• Product Name: Benzene, (1-fluoro-1-methylethyl)-
• CAS NO: 74185-81-2
• Molecular Formula: C9H11F
• Molecular Weight: 138.185
• Mol File: 74185-81-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, (1-fluoro-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (1-fluoro-1-methylethyl)-(74185-81-2)
• EPA Substance Registry System: Benzene, (1-fluoro-1-methylethyl)-(74185-81-2)

Safety Data

• Hazardous Substances Data: 74185-81-2(Hazardous Substances Data)

Upstream product

• 826-55-1 2-methyl-2-phenylpropionic acid 
• 98-82-8 Isopropylbenzene 
• 100-41-4 ethylbenzene 
• 108-88-3 toluene 
• 2241846-03-5 1,3-dioxoisoindolin-2-yl 2-methyl-2-phenylpropanoate 
• 24142-63-0 O-(methoxymethyl)-2-phenyl-2-propanol 
• 617-94-7 1-methyl-1-phenylethyl alcohol 

Relevant articles and documents

Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis

We report a redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters using an Ir photocatalyst under visible light irradiation. The method provides access to a broad range of aliphatic fluorides, including primary, secondary, and tertiary benzylic fluorides as well as unactivated tertiary fluorides, that are typically inaccessible by nucleophilic fluorination due to competing elimination. In addition, we show that the decarboxylative fluorination conditions are readily adapted to radiofluorination with [18F]KF. We propose that the reactions proceed by two electron transfers between the Ir catalyst and redox-active ester substrate to afford a carbocation intermediate that undergoes subsequent trapping by fluoride. Examples of trapping with O- and C-centered nucleophiles and deoxyfluorination via N-hydroxyphthalimidoyl oxalates are also presented, suggesting that this approach may offer a general blueprint for affecting redox-neutral SN1 substitutions under mild conditions.

Predictable site-selective radical fluorination of tertiary ethers

In this communication, we disclose the first example of metal-free and site-selective radical fluorination of readily available tertiary alkyl ethers, enabled by synergistic photocatalysis and organocatalysis. This catalytic combination allows for exclusi

Tetramethylfluoroformamidinium hexafluorophosphate (TFFH) as a mild deoxofluorination reagent

The solid, air-stable peptide coupling reagent TFFH (tetramethylfluoroformamidinium hexafluorophosphate) was found to activate a variety of alcohols towards deoxofluorination. These conditions are compatible with carbonyl functional groups thus offering interesting possibilities for the application to sensitive molecules. Georg Thieme Verlag Stuttgart · New York.