74192-65-7

Upstream product

• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 578-57-4 2-bromoanisole 
• 89393-50-0 benzyne 
• 31600-86-9 2-methoxyphenyllithium 
• 80762-49-8 2-(m-chlorophenyl)-4,4-dimethyl-4,5-dihydrooxazole 
• 74201-13-1 N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide 
• 579-75-9 2-Methoxybenzoic acid 
• 535-80-8 3-chlorobenzoate 
• 701923-86-6 3-Chloro-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide 
• 618-46-2 m-Chlorobenzoyl chloride 
• 21615-34-9 2-Methoxybenzoyl chloride 

Relevant academic research and scientific papers

Substituted pyranone inhibitors of cholesterol synthesis

The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acid of structural formula: STR1 are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.

Substituted pyranone inhibitors of cholesterol synthesis

6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

THE SYNTHESIS OF 1,2,3-TRISUBSTITUTED BENZENES. FURTHER COMMENTS ON BENZYNES DERIVED FROM ARYL OXAZOLINES

Further investigation of organolithium addition to the 2,3-benzyne of aryl oxazolines reveals that addition takes place to give the 3-lithio (kinetic) and/or 2-lithio (thermodynamic) products depending on the nature of the organolithium reagent.

SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS

6-Phenyl-, phenylalkyl-and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductas