742067-22-7

Usage

Chemical compound

2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester

Molecular weight

317.45 g/mol

Appearance

Colorless to light yellow liquid

Specific use

Building block for creating pharmaceuticals, agrochemicals, and other fine chemicals
Use in organic synthesis
Bistriflate derivative of a diamine carboxylic acid
Wide range of applications in research and development
Tailored applications based on specific needs

InChI:InChI=1/C14H26N2O4S/c1-13(2,3)20-12(17)15-8-5-14(11-15)6-9-16(10-7-14)21(4,18)19/h5-11H2,1-4H3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 336191-17-4 tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate 

Downstream Products

• 742067-21-6 8-methanesulfonyl-2,8-diaza-spiro[4.5]decane hydrochloride 

Relevant academic research and scientific papers

SPIRO-SUBSTITUTED PYRROLOPYRIMIDINES

The invention provides compounds of formula (I) or a pharmaceutically acceptable salt or ester thereof formula (I) wherein the symbols have the meaning as defined in the description. Said compounds are inhibitors of cathepsin K and/or cathepsin S and are useful for the treatment of diseases and medical conditions in which cathepsin K and/or cathepsin S is implicated, e.g. various disorders including neuropathic pain, inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, multiple sclerosis and tumours.

2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF

The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents -(CH2)t-O- or -(CH2)r-S-, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is -(CH2)j- or -CH=CH-, j is 1 or 2; p is 1 or 2, or Y is -(CH2)f-, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.