742079-59-0Relevant academic research and scientific papers
Second generation transition state analogue inhibitors of human 5′-methylthioadenosine phosphorylase
Evans, Gary B.,Furneaux, Richard H.,Lenz, Dirk H.,Painter, Gavin F.,Schramm, Vern L.,Singh, Vipender,Tyler, Peter C.
, p. 4679 - 4689 (2007/10/03)
The polyamine biosynthetic pathway is a therapeutic target for proliferative diseases because cellular proliferation requires elevated levels of polyamines. A byproduct of the synthesis of spermidine and spermine is 5′-methylthioadenosine (MTA). In humans
PROCESS FOR PREPARING INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES
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Page 26-27, (2010/02/08)
The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5'-methylthioadenosine phosphorylases (MTAP),
