7421-80-9Relevant academic research and scientific papers
A green and highly efficient protocol for catalyst-free Knoevenagel condensation and Michael addition of aromatic aldehydes with 1,3-cyclic diketones in PEG-400
Firouzeh, Nemati,Hossein, Kiani
experimental part, p. 2407 - 2410 (2012/02/04)
A convenient, highly efficient and green approach for synthesis of tetraketones from aromatic aldehydes with dimedone and 1,3-indanedione at room temperature in PEG-400 is described. The use of PEG-400 as the reaction medium and avoiding the use of any ca
Synthesis of tetraketones in water and under catalyst-free conditions
Yu, Jian-Jun,Wang, Li-Min,Liu, Jin-Qian,Guo, Feng-Lou,Liu, Ying,Jiao, Ning
scheme or table, p. 216 - 219 (2011/03/19)
A simple, environmentally friendly, tandem Knoevenagel condensation and Michael addition procedure is reported. The reactions between cyclic-13-diketones and a variety of aldehydes were carried out in water to afford tetraketones (64-99%). In this green synthetic protocol, the solvent water itself catalysed the reaction by hydrogen bonding, thus avoiding the use of any other catalysts to make the work up procedure easier.
Quantitative structure activity relationships for dicoumarol antivitamins K in the uncoupling of mitochondrial oxidative phosphorylation
Labbe Bois,Laruelle,Godfroid
, p. 85 - 90 (2007/10/05)
The dynamic structure of dicoumarol derivatives substituted on the methylene bridge was studied by nuclear magnetic resonance (nmr) spectroscopy. These molecules may be considered as dimers with restricted rotation around the methylene bridge, held by intramolecular hydrogen bonds; the presence of the substituent R modifies this dynamic process, mainly the facility of exchange of the 2 hydroxyl protons. These compounds were compared in respect of their potency in uncoupling oxidative phosphorylation in pig heart mitochondria; the data were correlated with constants used to characterize the substituent R; to make a potent uncoupler, R should be as small and as hydrophilic as possible. The results are discussed in consonance with the postulated mechanisms of action of the uncouplers, but no simple conclusion could be drawn, especially concerning the role of the dissociable protons.
