74213-41-5 Usage
Uses
Used in Organic Synthesis:
(TMethylsilyl)Methaneboronic acid is used as a reagent for the formation of carbon-carbon bonds through the Suzuki-Miyaura coupling reaction. Its versatility in undergoing various chemical reactions makes it a valuable tool for the preparation of a wide range of organic molecules.
Used in Pharmaceutical Industry:
(TMethylsilyl)Methaneboronic acid is used as a reagent in the synthesis of drug candidates. Its ability to form carbon-carbon bonds and participate in various chemical reactions contributes to the development of new pharmaceutical compounds.
Used in Production of Fine Chemicals:
(TMethylsilyl)Methaneboronic acid is used as a reagent in the production of fine chemicals. Its versatility and reactivity in chemical reactions make it a valuable component in the synthesis of high-quality specialty chemicals.
Safety Considerations:
(TMethylsilyl)Methaneboronic acid is a reactive and potentially hazardous compound. It should be handled with care and in accordance with proper safety protocols to ensure the safety of individuals and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 74213-41-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,2,1 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 74213-41:
(7*7)+(6*4)+(5*2)+(4*1)+(3*3)+(2*4)+(1*1)=105
105 % 10 = 5
So 74213-41-5 is a valid CAS Registry Number.
74213-41-5Relevant academic research and scientific papers
Practical and Modular Construction of C(sp3)-Rich Alkyl Boron Compounds
Yang, Yangyang,Tsien, Jet,Ben David, Ayala,Hughes, Jonathan M. E.,Merchant, Rohan R.,Qin, Tian
supporting information, p. 471 - 480 (2021/01/13)
Alkyl boronic acids and esters play an important role in the synthesis of C(sp3)-rich medicines, agrochemicals, and material chemistry. This work describes a new type of transition-metal-free mediated transformation to enable the construction of C(sp3)-rich and sterically hindered alkyl boron reagents in a practical and modular manner. The broad generality and functional group tolerance of this method is extensively examined through a variety of substrates, including synthesis and late-stage functionalization of scaffolds relevant to medicinal chemistry. The strategic significance of this approach, with alkyl boronic acids as linchpins, is demonstrated through various downstream functionalizations of the alkyl boron compounds. This two-step concurrent cross-coupling approach, resembling formal and flexible alkyl-alkyl couplings, provides a general entry to synthetically challenging high Fsp3-containing drug-like scaffolds.
Deprotonation of a Trimethylsilylmethaneboronic Ester
Matteson, Donald S.,Majumdar, Debesh
, p. 39 - 40 (2007/10/02)
Deprotonation of pinacol trimethylsilymethaneboronate yields an anion which reacts with carbonyl compounds to form alkeneboronic esters, or with alkyl halides to form α-trimethylsilylalkaneboronic esters.
