74226-22-5

Usage

Uses

Used in Pharmaceutical Research:
4-[2-(1H-Imidazol-1-yl)ethoxy]benzoic acid monohydrochloride is used as a potential enzyme inhibitor for [specific enzymes or pathways it targets], due to its unique chemical structure and properties that allow it to interact with biological targets.
Used in Drug Development:
In the field of drug development, 4-[2-(1H-Imidazol-1-yl)ethoxy]benzoic acid monohydrochloride is utilized as a lead compound for the design of new pharmaceuticals, leveraging its imidazole group for specific binding and activity against certain enzymes or biological processes.
Used in Biochemical Studies:
4-[2-(1H-Imidazol-1-yl)ethoxy]benzoic acid monohydrochloride serves as a subject of biochemical research to understand its interactions with biological systems, including its solubility, stability, and potential effects on enzymatic activity.

Upstream product

• 85938-29-0 1-acetyl-3-[2-(4-ethoxycarbonylphenoxy)ethyl]-imidazolium iodide 
• 38567-00-9 4-(2-Chloroethoxy)benzoic acid methyl ester 
• 36616-30-5 2-(4-carbamoylphenoxy)-ethyl chloride 
• 75912-57-1 4-<2-(1H-imidazol-1-yl)ethoxy>benzamide 
• 75912-98-0 methyl 4-<2-(1H-imidazol-1-yl)-ethoxy>-benzoate 

Downstream Products

• 75912-79-7 1-[2-(4-N,N-dimethylcarbamoylphenoxy)ethyl]imidazole 
• 75912-78-6 N-methyl-4-<2-(1H-imidazol-1-yl)ethoxy>benzamide 

Relevant academic research and scientific papers

N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromboxane synthetase enzyme and pharmaceutical compositions thereof

N-(mono or disubstituted phenoxyalkyl)imidazoles and the pharmaceutically acceptable acid addition salts thereof are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclooxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis, migraine, and the vascular complications of diabetes.

Selective Thromboxane Synthetase Inhibitors. 1. 1--1H-imidazoles

1-(2-Phenoxyethyl)-1H-imidazole was found to be an inhibitor of thromboxane (TxA2) synthetase, but it also inhibited the adrenal cytochrome P-450 enzyme steroid 11β-hydroxylase.The preparation of a series of analogues is described, and activity against TxA2 synthetase, PGI2 synthetase, cyclooxygenase, and steroid 11β-hydroxylase is discussed.Potency against TxA2 synthetase was increased by introduction of a carboxyl group at a suitable distance from the imidazole ring.A distance of 8.1-8.8 Angstroem between N-1 of the imidazole and the carboxyl carbon was found to be optimal.Introduction of a carboxyl group also had the effect of reducing activity against steroid 11β-hydroxylase.The most potent and selective compound was found to be 4-benzoic acid (14).

Certain pyridyloxy-or-thio-phenyl propenoic acid derivatives

Novel pyridine compounds and the pharmaceutically acceptable salts thereof having a specific inhibitory activity on thromboxane A2 biosynthesis in mammals useful for prevention and treatment of various disorders caused by thromboxane A2/s

Imidazole derivatives

The imidazole derivatives of the general formula: STR1 wherein A and B may be the same or different, and each is a straight- or branched-chain alkylene or alkenylene group having 1 to 8 carbon atoms, D is an acyl group having 2 to 10 carbon atoms, an alko