38567-00-9

Usage

General Description

4-(2-chloro-ethoxy)-benzoic acid methyl ester, also known as methyl 4-(2-chloroethoxy)benzoate, is a chemical compound with the molecular formula C10H11ClO3. It is a colorless to yellow liquid that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-(2-CHLORO-ETHOXY)-BENZOIC ACID METHYL ESTER is also a key building block for the production of various ester derivatives that have potential applications in the field of organic chemistry. It is important to handle this chemical with caution, as it can be harmful if ingested, inhaled, or in contact with skin. Additionally, it may cause irritation to the eyes, skin, and respiratory system.

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 16670-48-7 2-chloroethyl benzenesulfonate 
• 64-17-5 ethanol 
• 107-04-0 1-Bromo-2-chloroethane 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 107-06-2 1,2-dichloro-ethane 
• 3204-73-7 4-(2-hydroxyethoxy)benzoic acid methyl ester 
• 80-41-1 2-chloroethyl tosylate 

Downstream Products

• 133384-30-2 methyl 4-<2-(1H-pyrazol-1-yl)-ethoxy>-benzoate 
• 75912-98-0 methyl 4-<2-(1H-imidazol-1-yl)-ethoxy>-benzoate 
• 41074-02-6 4-methoxycarbonylphenyl vinyl ether 
• 133384-32-4 methyl 4-<2-(1H-pyrrol-1-yl)-ethoxy>-benzoate 
• 4204-60-8 1,2-bis(4-methoxycarbonylphenyl)-1,2-ethanediol 
• 65136-50-7 4-(2-chloro-ethoxy)-benzoyl chloride 
• 84541-38-8 [6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone 
• 84449-90-1 Raloxifen 
• 65136-51-8 4-(2-chloroethoxy)benzoic acid 
• 74226-22-5 4-[2-(1-imidazolyl)ethoxy]benzoic acid hydrochloride 
• 133384-27-7 methyl 4-<2-(1H-1,2,3-triazol-1-yl)-ethoxy>-benzoate 
• 133384-28-8 4-<2-(1H-1,2,3-triazol-1-yl)-ethoxy>-benzoic acid 
• 97988-29-9 4-<2-(1H-1,2,4-triazol-1-yl)-ethoxy>-benzoic acid 
• 133384-31-3 4-<2-(1H-pyrazol-1-yl)-ethoxy>-benzoic acid 

Relevant academic research and scientific papers

Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator

Estrogen receptors (ERs) play a major role in the growth of human breast cancer cells. A selective estrogen receptor down-regulator (SERD) that acts as not only an inhibitor of ligand binding, but also induces the down-regulation of ER, would be useful fo

Piperidine nucleophilic substitution without solvent: An efficient synthesis of raloxifene

Mild and high-yielding synthesis is described for raloxifene via piperdine nucleophilic substitution of a new raloxifene intermediate 3-aroyl-2-aryl-substituted benzo[b]thiophenes, which is obtained by acylation of para-substituted benzoyl chlorides and 2-arylbenzo[b]thiophenes. The key step is solvent free and offers valuable advantages, such as low cost, and is suitable for industrial production.

Palladium catalyzed chloroethoxylation of aromatic and heteroaromatic chlorides: An orthogonal functionalization of a chloroethoxy linker

A novel disconnection based on cross-coupling chemistry was designed to access pharmaceutically relevant aryl-aminoethyl ethers. The developed palladium-catalyzed functionalization of aryl- and heteroaryl chlorides with a sodium tetrakis-(2-chloroethoxy) borate salt is orthogonal to the simple nucleophilic replacement of the chloro function of the ethylene linker. The transformation enables efficient 2-chloroethoxylation in the absence of an additional external base. Subsequent amine substitution of the alkyl halide affords 2-aminoethoxy arenes. The applicability of this method was demonstrated through the synthesis of various aryl- and heteroaryl-alkyl ethers, including the intermediates of marketed drug molecules.

Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists

The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the conformationally restricted 4-aminopiperidine ring found in several series of CCR5 antagonists.

Benzothiophenes and related compounds as estrogen agonists

The invention is a compound of Formula (I): wherein R is —OH, R1is —OH, R2is —H, n is 2 or 3 and X is sulfur, or a pharmaceutically acceptable salt of a compound having Formula (1), or a pharmaceutical composition comprising a compou

Synthesis and preliminary use of novel acrylic ester-derived task-specific ionic liquids

Novel electrophilic alkenes bearing an ionic liquid-type appendage have been prepared and used in Diels-Alder cycloadditions, 1,4-additions, Heck couplings and Stetter reactions; this new type of support allows easy monitoring of the reactions by NMR and MS as well as simple and efficient work-up and isolation procedures.

Processes for preparing benzothiophenes

The present invention relates to intermediates and processes for preparing benzothiophenes.

Process for preparing benzothiophenes

The present invention relates to intermediates and processes for preparing benzothiophenes of the following formula: wherein Y is chloro, bromo, iodo or -SO2R9; and, R9is C1-C4alkyl, trifluoromethyl,

Anti-arrhythmic agents

A series of [N-alkyl-N-(nitro-, alkylsulphonamido, or amino-phenalkyl)amino]-alkyl, alkoxy or alkylthio phenyl derivatives having utility as anti-arrhythmic agents.