74295-86-6

Basic information

• Product Name: Monooctyl succinate
• Synonyms: Butanedioic acid 1-octyl ester;Monooctyl succinate;Succinic acid hydrogen 1-octyl ester
• CAS NO: 74295-86-6
• Molecular Formula: C12H22O4
• Molecular Weight: 230.3
• Mol File: 74295-86-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 88 °C
• Boiling Point: 347.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.024±0.06 g/cm3(Predicted)
• PKA: 4.45±0.17(Predicted)
• CAS DataBase Reference: Monooctyl succinate(CAS DataBase Reference)
• NIST Chemistry Reference: Monooctyl succinate(74295-86-6)
• EPA Substance Registry System: Monooctyl succinate(74295-86-6)

Safety Data

• Hazardous Substances Data: 74295-86-6(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 111-87-5 octanol 
• 110-15-6 succinic acid 

Relevant articles and documents

A comparative study of the thermal properties of homologous series of crystallisable n-alkyl maleate and itaconate monoesters

Homologous series of crystallisable C8-C22 even-numbered alkane oligomers with either maleate or itaconate monoesters end-groups were synthesized. Their total phase change enthalpy (ΔHtpce) and entropy (ΔStpce) on melting, determined by DSC, show a linear dependence with the number of carbons of the alkyl chain. A comparison was performed with corresponding succinate derivatives. The influence of the end functions on ΔStpce was examined in view of ΔStpce values estimated by the group additivity approach. A fair agreement between the experimental and the estimated entropy values could be demonstrated. Thermogravimetric analysis (TGA) has shown that the maleate oligomers are less stable than the corresponding succinate and itaconate derivatives. This behaviour could be confirmed by the activation energies of the degradation process.

LIPOPHILIC ANTICANCER DRUG COMPOUNDS, COMPOSITIONS AND RELATED METHODS

Lipophilic anticancer drug compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds.

Synthesis and investigation of N4-substituted cytarabine derivatives as prodrugs.

Esters of Cytarabine-N4-carboxylates 2a-i and succinamates 3a-f were synthesized as prodrugs of cytarabine (Ara-C) with the aim of developing improved derivatives for oral or parentral administration. At pH 2 series 2 showed relative higher stability than 3, while both series of esters revealed matched stability at pH 7. All esters were susceptible to enzymatic hydrolysis by rat plasma and liver homogenate with half lives ranged from 0.14 h to 12 d, and showed improved stability against cytidine deaminase. A parabolic relation was shown between Kobs of enzymatic hydrolysis and Vw. All compounds are more lipophilic than the parent drug, Ara-C.