743417-80-3

Basic information

• Product Name: methyl N-benzyl-piperidin-4-yl-cyanoacetate
• Synonyms: methyl N-benzyl-piperidin-4-yl-cyanoacetate
• CAS NO: 743417-80-3
• Molecular Weight: 272.347
• Mol File: 743417-80-3.mol

Chemical Properties

• CAS DataBase Reference: methyl N-benzyl-piperidin-4-yl-cyanoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-benzyl-piperidin-4-yl-cyanoacetate(743417-80-3)
• EPA Substance Registry System: methyl N-benzyl-piperidin-4-yl-cyanoacetate(743417-80-3)

Safety Data

• Hazardous Substances Data: 743417-80-3(Hazardous Substances Data)

Upstream product

• 616897-44-0 2-(1-benzylpiperidin-4-ylidene)malononitrile 
• 744195-35-5 N-benzyl-piperidin-4-yl-malonitrile 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 67-56-1 methanol 

Downstream Products

• 78056-67-4 1-(phenylmethyl)-4-piperidineacetonitrile 

Relevant articles and documents

Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease

Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's Disease were assayed. The optimum hybrid inhibitor 3 is much more potent and selective than tacrine in vitro. Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro.

Synthesis of some new 4-substituted N-benzyl-piperidines

Via Knoevenagel condensation of N-benzyl-4-piperidone with malononitrile some new 4-substituted N-benzyl-piperidines have been prepared. By means of these transformations an economic and large-scale synthesis of biologically important intermediate N-benzyl-piperidine-4-ethanol has been elaborated.