743472-03-9Relevant academic research and scientific papers
Short synthesis of the 6,6-spiroketal cores of spirofungins A and B
Dias, Luiz C.,De Oliveira, Luciana G.
, p. 2587 - 2590 (2004)
(Matrix Presented) Initial efforts toward the total synthesis of the antifungal antibiotics spirofungins A and B are reported. A short and efficient synthesis of the C9-C20 6,6-spiroketal fragments of both compounds is described. This asymmetric approach
Synthesis of the spirofungin a core via a domino strategy consisting of olefinic ester ring-closing metathesis and iodospiroacetalization
Neumaier, Jochen,Maier, Martin E.
supporting information; experimental part, p. 187 - 190 (2011/03/22)
Olefination of ester 26 which was obtained from acid 20 and alkenol 25 using a reduced titanium ethylidene reagent led to cyclic enol ether 28 which could be cyclized by iodospiroacetalization to the spiroacetal core of the antifungal compound spirofungin
