74352-31-1

Upstream product

• 110-86-1 pyridine 
• 74365-78-9 5'-O-monomethoxytritylthymidine 3'-O-(2-chlorophenyl) phosphoranilidate 
• 69320-80-5 o-chlorophenyl N-phenylphosphoramido chloridate 
• 76512-70-4 Phosphorobromidic acid 2-chloro-phenyl ester methyl ester 
• 42926-80-7 5'-O-monomethoxytritylthymidine 
• 14041-63-5 Phosphorous acid 2-chloro-phenyl ester dimethyl ester 
• 95-57-8 2-monochlorophenol 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 

Downstream Products

• 76524-44-2 C₄₈H₄₈ClN₄O₁₄P 
• 74352-35-5 C₃₈H₃₉Cl₂N₅O₁₄P₂ 
• 74352-34-4 C₅₂H₅₀Cl₂N₄O₁₆P₂*C₅H₅N 
• 74352-32-2 C₅₈H₅₅Cl₂N₅O₁₅P₂ 

Relevant academic research and scientific papers

2'-DEOXYRIBONUCLEOSIDE 3'-ARYL PHOSPHORANILIDATES KEY INTERMEDIATES IN THE STEREOSPECIFIC SYNTHESIS OF 2'-DEOXYRIBONUCLEOSIDE CYCLIC 3',5'-PHOSPHOROTHIOATES AND DINUCLEOSIDE(3'->5')-PHOSPHOROTHIOATES

Phosphorylation of the 5'-O-monomethoxytrityl-2'-deoxyribonucleosides by means of aryl phosphoranilidochloridates gives the diastereomers of 5'-O-monomethoxytrityl-2'-deoxyribonucleoside 3'-aryl phosphoranilidates.Their separation can be performed by mean

ALKYL ARYL BROMOPHOSPHATES: NOUVEAUX REACTIFS DE PHOSPHORYLATION

La reaction des bromophosphates (5) avec le 5'-O-monomethoxytritylthymidine dans la pyridine conduit facilement soit au nucleoside-3'-phosphotriester (7), soit au nucleoside 3'-phosphodiester (8) selon l'ordre d'addition des reactifs.