74405-07-5

Basic information

• Product Name: 2-Chloro-2,2-dimethyl-2H-1,3-benzoxazine
• Synonyms: 2-Chloro-2,2-dimethyl-2H-1,3-benzoxazine;4-chloro-2,2-diMethyl-2H-benzo[e][1,3]oxazine;4-Chloro-2,2-dimethyl-2H-1,3-benzoxazine
• CAS NO: 74405-07-5
• Molecular Formula: C₁₀H₁₀ClNO
• Molecular Weight: 195.65
• Product Categories: Aromatics;Heterocycles
• Mol File: 74405-07-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 85-86℃ (2.5 Torr)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• PKA: 0.05±0.40(Predicted)
• CAS DataBase Reference: 2-Chloro-2,2-dimethyl-2H-1,3-benzoxazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-2,2-dimethyl-2H-1,3-benzoxazine(74405-07-5)
• EPA Substance Registry System: 2-Chloro-2,2-dimethyl-2H-1,3-benzoxazine(74405-07-5)

Safety Data

• Hazardous Substances Data: 74405-07-5(Hazardous Substances Data)

Usage

Uses

2-Chloro-2,2-dimethyl-2H-1,3-benzoxazine is an important synthetic intermediate.

Upstream product

• 30914-88-6 2,2-dimethyl-4-keto-1,3-benzoxazine 
• 10025-87-3 trichlorophosphate 
• 65-45-2 salicylamide 

Downstream Products

• 38198-16-2 4-methyl-pyridin-2-ylmethyl chloride 
• 75523-42-1 2-methyl-pyridin-4-ylmethyl chloride 
• 76823-06-8 2,2-Dimethyl-3-(4-methyl-pyridin-2-ylmethyl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one; hydrochloride 
• 76809-19-3 2,2-Dimethyl-3-(2-methyl-pyridin-4-ylmethyl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one; hydrochloride 
• 83939-74-6 2,2-dimethyl-4-<2-(2-hydroxyethyl)phenyl>amino-2H-1,3-benzoxazine 
• 3411-95-8 2-(benzothiazol-2-yl)phenol 
• 10445-91-7 4-(Chloromethyl)pyridine 
• 30914-88-6 2,2-dimethyl-4-keto-1,3-benzoxazine 
• 76809-17-1 2,2-dimethyl-3-(4-pyridylmethyl)-4-oxo-4H-1,3-benzoxazine 
• 76809-27-3 2,2-dimethyl-3-(4-methylpyrid-3-yl)-4-oxo-4H-1,3-benzoxazine 
• 76809-23-9 2,2-dimethyl-3-(4-methylpyrid-2-yl)-4-oxo-4H-1,3-benzoxazine 
• 13563-04-7 N-(2'-pyridyl)-2-hydroxybenzamide 
• 25171-21-5 2-(2-hydroxyphenyl)-4-phenylquinazoline 
• 52537-82-3 2-(6-chloro-4-phenylquinazoline-2-yl)phenol 

Relevant articles and documents

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Studies on 1,3-Benzoxazines. I. Synthesis of Primary 2-Amino-pyridines via the Reaction of Imidoyl Chlorides of 1,3-Benzoxazines with Pyridine N-Oxides

A new synthetic method for primary 2-aminopyridine derivatives is described.Treatment of the imidoyl chlorides of 1,3-benzoxazines (1a-i) with pyridine N-oxides resulted in the introduction of an oxazine moiety into the α-position of the pyridine ring through rearrangement of the initially formed reaction adduct.Acid hydrolysis of the rearrangement products afforded 2-aminopyridine derivatives in excellent yields.When methoxypyridine N-oxides were used, products of a different type (10 and 14) were obtained.