74405-07-5

Usage

Uses

2-Chloro-2,2-dimethyl-2H-1,3-benzoxazine is an important synthetic intermediate.

Upstream product

• 30914-88-6 2,2-dimethyl-4-keto-1,3-benzoxazine 
• 10025-87-3 trichlorophosphate 
• 65-45-2 salicylamide 

Downstream Products

• 10445-91-7 4-(Chloromethyl)pyridine 
• 30914-88-6 2,2-dimethyl-4-keto-1,3-benzoxazine 
• 76809-17-1 2,2-dimethyl-3-(4-pyridylmethyl)-4-oxo-4H-1,3-benzoxazine 
• 76809-27-3 2,2-dimethyl-3-(4-methylpyrid-3-yl)-4-oxo-4H-1,3-benzoxazine 
• 76809-23-9 2,2-dimethyl-3-(4-methylpyrid-2-yl)-4-oxo-4H-1,3-benzoxazine 
• 4377-33-7 2-chloromethylpyridine 
• 76809-31-9 2,2-dimethyl-3-(2-methylpyrid-5-yl)-4-oxo-4H-1,3-benzoxazine 
• 76809-24-0 2,2-dimethyl-3-(2-methylpyrid-3-yl)-4-oxo-4H-1,3-benzoxazine 
• 76809-21-7 2,2-dimethyl-3-(6-methylpyrid-2-yl)-4-oxo-4H-1,3-benzoxazine 
• 76809-35-3 2,2-dimethyl-3-(2-pyridylmethyl)-4-oxo-4H-1,3-benzoxazine 
• 82562-63-8 2-(2-hydroxyphenyl)-4H-3,1-benzoxazine 
• 3099-29-4 2-(chloromethyl)-6-methylpyridine 
• 76809-18-2 2,2-Dimethyl-3-(6-methyl-pyridin-2-ylmethyl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one 
• 76809-28-4 3-(2,6-Dimethyl-pyridin-3-yl)-2,2-dimethyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one 

Relevant academic research and scientific papers

HETEROARYLS AMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATORS

The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R1, R2, R3, and R4 are as described herein.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.

Total syntheses of 6- and 7-azaindole derived GnRH antagonists

The palladium(0)-catalyzed heteroannulation of a triethylsilyl alkyne and an ortho-aminoiodopyridine derivative is used as the key step in a highly convergent route to 6- and 7-azaindoles of biological interest.

Sulfonamide-substituted compounds, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparation comprising them

Compounds of formula I STR1 having the meanings indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and therapy of cardiovascular disorders, in particular arrhythmias; for the treatment of ulce

Studies on 1,3-Benzoxazines. I. Synthesis of Primary 2-Amino-pyridines via the Reaction of Imidoyl Chlorides of 1,3-Benzoxazines with Pyridine N-Oxides

A new synthetic method for primary 2-aminopyridine derivatives is described.Treatment of the imidoyl chlorides of 1,3-benzoxazines (1a-i) with pyridine N-oxides resulted in the introduction of an oxazine moiety into the α-position of the pyridine ring through rearrangement of the initially formed reaction adduct.Acid hydrolysis of the rearrangement products afforded 2-aminopyridine derivatives in excellent yields.When methoxypyridine N-oxides were used, products of a different type (10 and 14) were obtained.