3099-29-4

Basic information

• Product Name: 2-(CHLOROMETHYL)-6-METHYLPYRIDINE
• Synonyms: 2-Chloromethyl-6-methylpyridine;2-(chloromethyl)-6-methylpyridine(SALTDATA: HCl);Pyridine, 2-(chloromethyl)-6-methyl-;EOS-62430
• CAS NO: 3099-29-4
• Molecular Formula: C₇H₈ClN
• Molecular Weight: 141.6
• Product Categories: Heterocycle-Pyridine series
• Mol File: 3099-29-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 159-161 °C
• Boiling Point: 196.1 °C at 760 mmHg
• Flash Point: 90.2 °C
• Appearance: /
• Density: 1.118 g/cm³
• Vapor Pressure: 0.57mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.43±0.12(Predicted)
• CAS DataBase Reference: 2-(CHLOROMETHYL)-6-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-6-METHYLPYRIDINE(3099-29-4)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-6-METHYLPYRIDINE(3099-29-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 3099-29-4(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-6-methylpyridine is a chemical compound that belongs to the class of pyridine derivatives. It has a molecular formula C7H8ClN and a molecular weight of 143.59 g/mol. 2-(CHLOROMETHYL)-6-METHYLPYRIDINE is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is known to be a highly reactive and potentially hazardous compound, and proper safety precautions must be taken when handling it. 2-(Chloromethyl)-6-methylpyridine is also known by its CAS number 32023-21-3 and is available as a commercial product for industrial and research purposes.

InChI:InChI=1/C7H8ClN/c1-6-3-2-4-7(5-8)9-6/h2-4H,5H2,1H3

Upstream product

• 1122-71-0 2-(Hydroxymethyl)-6-methylpyridine 
• 108-48-5 2,6-dimethylpyridine 
• 6890-58-0 2,6-dimethylpyridine N-oxide hydrochloride 
• 10025-87-3 trichlorophosphate 
• 1122-72-1 6-methyl-2-pyridinecarboxaldehyde 
• 13602-11-4 6-methylpicolinic acid methyl ester 
• 13287-64-4 acetic acid 6-methyl-pyridin-2-ylmethyl ester 
• 1073-23-0 2,6-lutidine N-oxide 
• 74405-07-5 4-chloro-2,2-dimethyl-2H-benzo[e][1,3]oxazine 

Downstream Products

• 39077-66-2 3-(6-methyl-pyridin-2-yl)-2-phenyl-propionitrile 
• 92814-12-5 2-Methyl-6-{4-[1-(2-methoxyphenyl)-1-hydroxypropyl]-phenoxymethyl}-pyridine 
• 1454918-37-6 C₂₂H₁₉N₃O₂S 
• 1313408-93-3 3-bromo-1-((6-methylpyridin-2-yl)methyl)-4-nitro-1H-indazole 
• 790235-48-2 N,N-bis(6-methyl-2-picolyl)-p-tolylsulfonamide 
• 92814-05-6 2-methyl-6-{4-[1-(4-chlorophenyl)-1-hydroxypropyl]-phenoxymethyl}-pyridine 
• 790235-49-3 C₅₂H₅₁N₅O₁₁S 

Relevant articles and documents

Synthesis of 2-aminomethylpyridene-appended [60]fullerenes. On the difference in the metal-binding properties between 5,6-open and 6,6-closed isomers

Two 2-aminomethylpyridine-appended [60]fullerenes (1) with the 5,6-open and the 6,6-closed structure were synthesized in order to examine the influence of the structural difference on the metal-binding ability. Both compounds could form the 1:1 complex with Ag+ but the Kass for 5,6-1 was larger by more than two orders of magnitude than that for 6,6-1.

Rapid and Effective Reaction of 2-Methylpyridin-N-oxides with Triphosgene via a [3,3]-Sigmatropic Rearrangement: Mechanism and Applications

A facile and effective synthesis of 2-chloromethylpyridines was developed by a one-pot reaction of 2-alkylpyridin-N-oxides and triphosgene at room temperature. As starting materials, N-oxides of 2-alkylpyridine derivatives, including 2-alkylpyridines, 2-methyl quinolines, and phenanthroline, can react rapidly with triphosgene in the presence of triethylamine, affording 2-chloromethylpyridines in good to excellent yields (52-95%). Using the 2-methylquinoline substrate for the mechanistic study, it has been well demonstrated that the chlorination reaction undergoes a [3,3]-sigmatropic rearrangement, which can be observed as a reversible process by monitoring the intermediates. Moreover, the chlorination reaction can be used to construct a rapid and sensitive fluorescent probe for the detection of phosgene.

Selective recognition of HIV RNA by dinuclear metallic ligands

We describe the development of dinuclear metallic ligands to target specific HIV RNA structures. Two series of dipyridinyl-N bridged dinuclear metal complexes were synthesized in moderate to good yields and their binding activities toward TAR and RRE RNA were studied both experimentally and theoretically. The docking calculation elucidated some structure features in dimetallic complexes that can affect TAR RNA-binding properties.